Litovitz T L, Klein-Schwartz W, Oderda G M, Matyunas N J, Wiley S, Gorman R L
Pediatrics. 1985 Nov;76(5):761-4.
The efficacy of ipecac syrup in the induction of emesis and safety of its administration was studied in 105 poison-exposed infants 6 through 11 months of age (study subjects) and compared prospectively with 302 poison-exposed infants and children 12 through 35 months of age who served as age controls. Of the 105 study subjects 101 (96.2%) vomited. The failure of ipecac to induce emesis in six patients (four of 105 study subjects two of 302 age control subjects) is comparable with ipecac failure rates reported elsewhere. The frequency of side effects caused by ipecac syrup did not differ between study and control subjects. There were no serious medical complications resulting from the administration of ipecac syrup. When not readily available at home, ipecac administration was delayed an additional 21.8 minutes if obtained from a pharmacy and 38.4 minutes if obtained from an emergency department. Because of the time delay and the increased health care cost, home rather than emergency department administration of ipecac should be advised. These data demonstrate that ipecac syrup effectively induces emesis and is safe for home administration to poisoned infants 6 to 11 months old.
对105名6至11个月大的中毒婴儿（研究对象）进行了吐根糖浆催吐效果及其用药安全性的研究，并与302名12至35个月大的中毒婴儿及儿童（作为年龄对照）进行了前瞻性比较。在105名研究对象中，有101名（96.2%）出现呕吐。6名患者（105名研究对象中的4名，302名年龄对照对象中的2名）使用吐根未能催吐，这与其他地方报道的吐根失败率相当。吐根糖浆引起的副作用发生率在研究对象和对照对象之间没有差异。服用吐根糖浆未导致严重的医学并发症。如果家里没有现成的吐根糖浆，从药房获取会使给药延迟额外21.8分钟，从急诊科获取则会延迟38.4分钟。由于存在时间延迟且医疗保健成本增加，建议在家中而非急诊科使用吐根糖浆。这些数据表明，吐根糖浆能有效催吐，对6至11个月大的中毒婴儿在家中给药是安全的。
