a Department of Geriatric Psychiatry , Qingdao Mental Health Center , Qingdao , P.R. China.
Int J Psychiatry Clin Pract. 2018 Mar;22(1):2-5. doi: 10.1080/13651501.2017.1341986. Epub 2017 Jun 28.
This paper reviewed the relevant literature on the effects of lamotrigine on pregnancy outcomes to provide useful information regarding lamotrigine use in pregnant women with bipolar disorder.
A systematic search of electronic databases and other original sources was conducted that examined the effects of lamotrigine on pregnancy outcomes.
It is not clear that foetuses of lamotrigine-exposed pregnant women are at higher risk of malformation or neurodevelopmental delay. When treating pregnant women with bipolar disorder, the risks associated with lamotrigine use have to be balanced with the risks of uncontrolled maternal symptoms. The information obtained from our review of psychotropic medications will assist clinicians in managing pregnant women with bipolar disorder.
Although lamotrigine has emerged as the safest mood stabiliser for use during pregnancy based on the clinical evidence thus far, further studies are needed to inform the best clinical practice when treating bipolar disorder in pregnant women.
本文回顾了有关拉莫三嗪对妊娠结局影响的相关文献，为患有双相情感障碍的孕妇使用拉莫三嗪提供有用的信息。
系统地检索了电子数据库和其他原始资料，以研究拉莫三嗪对妊娠结局的影响。
目前尚不清楚暴露于拉莫三嗪的孕妇的胎儿畸形或神经发育迟缓的风险更高。在治疗患有双相情感障碍的孕妇时，必须权衡使用拉莫三嗪的风险与未控制的母体症状的风险。从我们对精神药物的审查中获得的信息将有助于临床医生管理患有双相情感障碍的孕妇。
尽管到目前为止，基于临床证据，拉莫三嗪已成为怀孕期间使用最安全的情绪稳定剂，但仍需要进一步的研究来为治疗孕妇双相情感障碍提供最佳的临床实践。
