Burton M Caroline, Koeller Sandra L, Brekke Frank M, Afonya Adonye T, Sutor Bruce, Lapid Maria I
J ECT. 2017 Dec;33(4):286-289. doi: 10.1097/YCT.0000000000000432.
This naturalistic prospective observation study examines the efficacy of electroconvulsive therapy (ECT) in treating dementia-related agitation.
Patients with dementia-related agitation who received ECT were compared with patients with the same condition who did not receive ECT using Cohen-Mansfield Agitation Inventory (CMAI), Neuropsychiatric Inventory (NPI)-nursing home version, and Clinical Global Impression Scale (CGI). Outcomes were compared between ECT-treated and non-ECT-treated patients.
A total of 9 patients were included in the study. Six received ECT, and 3 did not. Patients in the ECT and non-ECT-treated groups had comparable baseline scores (CMAI, P = 0.880; NPI, P = 0.814; and CGI, P = 0.445). The CMAI, NPI, and CGI scores were lower on final assessment in both groups with no statistically significant difference (CMAI, P = 0.771; NPI, P = 0.243; and CGI, P = 0.519).
Electroconvulsive therapy should be considered as a treatment option in the management of severe treatment refractory dementia-related agitation.
本自然主义前瞻性观察研究探讨了电休克疗法（ECT）治疗痴呆相关激越的疗效。
使用科恩-曼斯菲尔德激越量表（CMAI）、神经精神科问卷（NPI）-疗养院版和临床总体印象量表（CGI），将接受ECT治疗的痴呆相关激越患者与未接受ECT治疗的同病情患者进行比较。比较ECT治疗组和非ECT治疗组的结果。
共有9名患者纳入研究。6名接受ECT治疗，3名未接受。ECT治疗组和非ECT治疗组患者的基线评分相当（CMAI，P = 0.880；NPI，P = 0.814；CGI，P = 0.445）。两组最终评估时CMAI、NPI和CGI评分均较低，无统计学显著差异（CMAI，P = 0.771；NPI，P = 0.243；CGI，P = 0.519）。
电休克疗法应被视为治疗严重难治性痴呆相关激越的一种治疗选择。
