Kramer Andrew A, Dasta Joseph F, Kane-Gill Sandra L
1Prescient Healthcare Consulting, Charlottesville, VA. 2Division of Pharmacy Practice and Science, The Ohio State University, Columbus, OH. 3Division of Health Outcomes & Pharmacy Practice, The University of Texas, Austin, TX. 4Critical Care Medicine, Biomedical Informatics and Clinical Translational Sciences, University of Pittsburgh, Pittsburgh, PA.
Crit Care Med. 2017 Sep;45(9):1457-1463. doi: 10.1097/CCM.0000000000002563.
The high cost of critical care has engendered research into identifying influential factors. However, existing studies have not considered patient vital status at ICU discharge. This study sought to determine the effect of mortality upon the total cost of an ICU stay.
Retrospective cohort study.
Twenty-six ICUs at 13 hospitals in the United States.
58,344 admissions from January 1, 2012, to June 30, 2016, obtained from a commercial ICU database.
None.
The median observed cost of a unit stay was $9,619 (mean = $16,353). A multivariable regression model was developed on the log of total costs for a unit stay, using severity of illness, unit admitting diagnosis, mortality in the unit, daily unit occupancy (occupying a bed at midnight), and length of mechanical ventilation. This model had an r of 0.67 and a median difference between observed and expected costs of $437. The first few days of care and the first day receiving mechanical ventilation had the largest effect on total costs. Patients dying before unit discharge had 12.4% greater costs than survivors (p < 0.01; 99% CI = 9.3-15.5%) after multivariable adjustment. This effect was most pronounced for patients with an extended ICU stay who were receiving mechanical ventilation.
While the largest drivers of ICU costs at the patient level are day 1 room occupancy and day 1 mechanical ventilation, mortality before unit discharge is associated with substantially higher costs. The increase was most evident for patients with an extended ICU stay who were receiving mechanical ventilation. Studies evaluating costs among ICUs need to take mortality into account.
重症监护的高昂成本促使人们开展研究以确定影响因素。然而,现有研究未考虑患者在重症监护病房(ICU)出院时的生命状态。本研究旨在确定死亡率对ICU住院总费用的影响。
回顾性队列研究。
美国13家医院的26个ICU。
从商业ICU数据库获取的2012年1月1日至2016年6月30日期间的58344例入院患者。
无。
一个单位住院期间的观察到的费用中位数为9619美元(均值=16353美元)。基于单位住院总费用的对数建立了一个多变量回归模型,使用疾病严重程度、单位收治诊断、单位内死亡率、每日单位占用率(午夜占用床位情况)以及机械通气时长。该模型的r值为0.67,观察到的费用与预期费用之间的中位数差异为437美元。护理的头几天以及接受机械通气的第一天对总费用的影响最大。在多变量调整后,在单位出院前死亡的患者比幸存者的费用高12.4%(p<0.01;99%置信区间=9.3 - 15.5%)。这种影响在接受机械通气且ICU住院时间延长的患者中最为明显。
虽然在患者层面,ICU费用的最大驱动因素是第一天的病房占用率和第一天的机械通气,但单位出院前的死亡率与显著更高的费用相关。这种增加在接受机械通气且ICU住院时间延长的患者中最为明显。评估ICU之间费用的研究需要考虑死亡率。