Emamifar Amir, Hess Søren, Gerke Oke, Hermann Anne Pernille, Laustrup Helle, Hansen Per Syrak, Thye-Rønn Peter, Marcussen Niels, Svendstrup Frank, Gildberg-Mortensen Rannveig, Bang Jacob Christian, Farahani Ziba Ahangarani, Chrysidis Stavros, Toftegaard Pia, Andreasen Rikke Asmussen, le Greves Sebastian, Andersen Hanne Randi, Olsen Rudolf Nezlo, Hansen Inger Marie Jensen
Department of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg Faculty of Health Sciences, University of Southern Denmark Department of Nuclear Medicine, Odense University Hospital, Odense Department of Radiology and Nuclear Medicine, Hospital Southwest Jutland, Esbjerg Centre of Health Economics Research, University of Southern Denmark Department of Endocrinology Department of Rheumatology, Odense University Hospital, Odense Diagnostic center, Odense University Hospital, Svendborg Hospital, Svendborg Department of Pathology, Odense University Hospital, Odense Department of Ear Nose Throat Surgery Department of Radiology, Odense University Hospital, Svendborg Hospital, Svendborg Department of Rheumatology, Hospital Southwest Jutland, Esbjerg Patient Research Partner, Department of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg, Denmark.
Medicine (Baltimore). 2017 Jun;96(26):e7297. doi: 10.1097/MD.0000000000007297.
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to assess global disease activity in inflammatory diseases. 18F-FDG PET/CT may lead to the diagnosis at an earlier stage than conventional imaging and may also assess response to therapy. With respect to the management of PMR/GCA, there are 3 significant areas of concern as follows: vasculitis process/vascular stiffness, malignancy, and osteoporosis.
All patients with suspected PMR/GCR referred to the Rheumatology section of Medicine Department at Svendborg Hospital, Denmark. The 4 separate studies in the current protocol focus on: the association of clinical picture of PMR/GCA with PET findings; the validity of 18F-FDG PET/CT scan for diagnosis of PMR/GCA compared with temporal artery biopsy; the prevalence of newly diagnosed malignancies in patients with PMR/GCA, or PMR-like syndrome, with the focus on diagnostic accuracy of 18F-FDG PET/CT scan compared with conventional workup (ie, chest X-ray/abdominal ultrasound); and the impact of disease process, and also steroid treatment on bone mineral density, body composition, and vasculitis/vascular stiffness in PMR/GCA patients.
The study has been approved by the Regional Ethics Committee of the Region of Southern Denmark (identification number: S-20160098) and Danish Data Protection Agency (J.nr 16/40522). Results of the study will be disseminated via publications in peer-reviewed journals, and presentation at national and international conferences.
风湿性多肌痛（PMR）和巨细胞动脉炎（GCA）是常见的炎症性疾病。由于没有特异性诊断检测方法，PMR/GCA的诊断面临诸多挑战。近期文献强调了18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）评估炎症性疾病整体疾病活动的能力。18F-FDG PET/CT可能比传统成像更早地做出诊断，还可评估治疗反应。关于PMR/GCA的管理，有3个重要关注领域如下：血管炎进程/血管僵硬度、恶性肿瘤和骨质疏松症。
所有疑似PMR/GCR的患者均转诊至丹麦斯文堡医院内科的风湿病科。当前方案中的4项独立研究聚焦于：PMR/GCA的临床表现与PET检查结果的关联；与颞动脉活检相比，18F-FDG PET/CT扫描对PMR/GCA诊断的有效性；PMR/GCA或PMR样综合征患者中新诊断恶性肿瘤的患病率，重点是与传统检查（即胸部X线/腹部超声）相比18F-FDG PET/CT扫描的诊断准确性；以及疾病进程和类固醇治疗对PMR/GCA患者骨密度、身体成分以及血管炎/血管僵硬度的影响。
该研究已获得丹麦南部地区伦理委员会（识别号：S-20160098）和丹麦数据保护局（J.nr 16/40522）的批准。研究结果将通过在同行评审期刊上发表以及在国内和国际会议上报告进行传播。
