Houshmand Sina, Salavati Ali, Hess Søren, Werner Thomas J, Alavi Abass, Zaidi Habib
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Nuclear Medicine, Odense University Hospital, Søndre Boulevard 29, Odense 5000, Denmark.
PET Clin. 2015 Jan;10(1):45-58. doi: 10.1016/j.cpet.2014.09.004. Epub 2014 Nov 22.
Since its foundation PET has established itself as one of the standard imaging modalities enabling the quantitative assessment of molecular targets in vivo. In the past two decades, quantitative PET has become a necessity in clinical oncology. Despite introduction of various measures for quantification and correction of PET parameters, there is debate on the selection of the appropriate methodology in specific diseases and conditions. In this review, we have focused on these techniques with special attention to topics such as static and dynamic whole body PET imaging, tracer kinetic modeling, global disease burden, texture analysis and radiomics, dual time point imaging and partial volume correction.
自成立以来，正电子发射断层扫描（PET）已成为标准成像模式之一，能够在体内对分子靶点进行定量评估。在过去二十年中，定量PET已成为临床肿瘤学的一项必要手段。尽管引入了各种PET参数定量和校正措施，但在特定疾病和情况下，对于选择合适的方法仍存在争议。在本综述中，我们重点关注了这些技术，特别关注了静态和动态全身PET成像、示踪剂动力学建模、整体疾病负担、纹理分析和放射组学、双时间点成像以及部分容积校正等主题。
