Aquino Ranniere Gurgel Furtado DE, Vasques Paulo Henrique Diógenes, Cavalcante Diane Isabelle Magno, Oliveira Ayane Layne DE Sousa, Oliveira Bruno Masato Kitagawa DE, Pinheiro Luiz Gonzaga Porto
- Federal University of Ceará (UFC), Post-graduation Program in Surgery, Fortaleza, Ceara State, Brazil.
- University of Fortaleza (UNIFOR), Faculty of Medicine, Fortaleza, Ceara State, Brazil.
Rev Col Bras Cir. 2017 Mar-Apr;44(2):163-170. doi: 10.1590/0100-69912017002010.
to analyze the relation of anatomopathological features and axillary involvement in cases of invasive ductal carcinoma.
this is a cross-sectional study of 220 breast cancer patients submitted to radical mastectomy or quadrantectomy with axilar emptying, from the Mastology Service of the Assis Chateaubriand Maternity School, Ceará, Brazil. We submitted the tumors to histological processing and determined the histological (HG), tubular (TG) and nuclear (NG) grades, and the mitotic index (MI) by the classification of Scarff-Bloom-Richadson, verified the presence of angiolymphatic invasion (AI) and measured the largest tumor diameter (TD). We then correlated these variables with the presence of axillary metastases.
the mean patients'age was 56.81 years ± 13.28. Tumor size ranged from 0.13 to 22 cm, with an average of 2.23cm ± 2.79. HG3, TG3 and NG3 prevailed, respectively 107 (48.6%), 160 (72.7%) and 107 (48.6%). Mitotic indexes 1, 2 and 3 presented a homogeneous distribution, respectively 82 (37.2%), 68 (31%) and 70 (31.8%). We observed no relation between the HG, TG and NG with the occurrence of axillary metastases (p=0.07, p=0.22 and p=0.21, respectively). Mitotic indices 2 and 3 were related with the occurrence of axillary metastases (p=0.03). Tumors larger than 2cm and cases that presented angiolymphatic invasion had a higher index of axillary metastases (p=0.0003 and p<0.0001).
elevated mitotic indexes, tumors with a diameter greater than 2cm and the presence of angiolymphatic invasion were individuallyassociatedwith the occurrence of axillary metastases.
分析浸润性导管癌病例的解剖病理学特征与腋窝受累情况之间的关系。
这是一项横断面研究，研究对象为220例接受根治性乳房切除术或象限切除术并清扫腋窝的乳腺癌患者，这些患者来自巴西塞阿拉州阿西斯·夏多布里昂妇产学校乳腺科。我们对肿瘤进行组织学处理，根据斯卡夫-布卢姆-理查森分类法确定组织学分级（HG）、管状分级（TG）和核分级（NG）以及有丝分裂指数（MI），核实血管淋巴管浸润（AI）的存在情况，并测量肿瘤最大直径（TD）。然后我们将这些变量与腋窝转移的存在情况进行关联分析。
患者平均年龄为56.81岁±13.28岁。肿瘤大小从0.13厘米至22厘米不等，平均为2.23厘米±2.79厘米。HG3、TG3和NG3占主导，分别为107例（48.6%）、160例（72.7%）和107例（48.6%）。有丝分裂指数1、2和3呈现均匀分布，分别为82例（37.2%）、68例（31%）和70例（31.8%）。我们观察到HG、TG和NG与腋窝转移的发生之间无关联（p值分别为0.07、0.22和0.21）。有丝分裂指数2和3与腋窝转移的发生相关（p=0.03）。直径大于2厘米的肿瘤以及出现血管淋巴管浸润的病例腋窝转移指数更高（p=0.0003和p<0.0001）。
有丝分裂指数升高、直径大于2厘米的肿瘤以及血管淋巴管浸润的存在均与腋窝转移的发生单独相关。
