Xu Miao, Dong Chen
Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China.
Immunol Rev. 2017 Jul;278(1):185-191. doi: 10.1111/imr.12558.
IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer. This review summarizes the literature on IL-25 and discusses the unsolved questions. Our knowledge on IL-25 will pave the pathway for targeting this cytokine in inflammatory diseases.
白细胞介素-25（IL-25），也被称为IL-17E，是IL-17细胞因子家族的成员之一，主要由上皮细胞和固有免疫细胞产生。IL-25与IL-17RB/IL-17RA复合物结合后，可在上皮细胞和2型淋巴细胞中诱导下游信号反应，从而启动、传播并维持2型免疫反应。IL-25在哮喘等过敏性疾病中的作用已得到充分证实，目前其作用范围也扩展到了炎症性肠病和癌症等疾病。本综述总结了关于IL-25的文献，并讨论了尚未解决的问题。我们对IL-25的了解将为在炎症性疾病中靶向作用于这种细胞因子铺平道路。
