Huang Liqing
Three Gorges University Hospital of Traditional Chinese Medicine & Yichang Hospital of Traditional Chinese Medicine, Yichang, China.
Front Cardiovasc Med. 2024 Oct 22;11:1470362. doi: 10.3389/fcvm.2024.1470362. eCollection 2024.
Myocardial fibrosis is a common pathological feature in various cardiovascular diseases including myocardial infarction, heart failure, and myocarditis. Generally, persistent myocardial fibrosis correlates with poor prognosis and ranks among the leading causes of death globally. Currently, there is no effective treatment for myocardial fibrosis, partly due to its unclear pathogenic mechanism. Increasing studies have shown IL-17 family cytokines are strongly associated with the initiation and propagation of myocardial fibrosis. This review summarizes the expression, action, and signal transduction mechanisms of IL-17, focusing on its role in fibrosis associated with cardiovascular diseases such as myocardial infarction, heart failure, hypertension, diabetes, and myocarditis. It also discusses its potential as a therapeutic target, offering new insights for the clinical treatment of myocardial fibrosis.
心肌纤维化是包括心肌梗死、心力衰竭和心肌炎在内的各种心血管疾病的常见病理特征。一般来说，持续性心肌纤维化与不良预后相关，是全球主要死因之一。目前，心肌纤维化尚无有效的治疗方法，部分原因是其致病机制尚不清楚。越来越多的研究表明，白细胞介素-17（IL-17）家族细胞因子与心肌纤维化的发生和发展密切相关。本文综述了IL-17的表达、作用及信号转导机制，重点阐述了其在心肌梗死、心力衰竭、高血压、糖尿病和心肌炎等心血管疾病相关纤维化中的作用。此外，还讨论了其作为治疗靶点的潜力，为心肌纤维化的临床治疗提供了新的思路。
