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误诊为胃类癌的胃血管球瘤:一种不常见的实体瘤及诊断要点与文献复习

Gastric Glomus Tumour Misdiagnosed as Gastric Carcinoid: An Unfamiliar Entity with Aids to Diagnosis and Review of Literature.

作者信息

Vig Tanush, Bindra Mandeep Singh, Kumar Ramani Manoj, Alexander Suceena

机构信息

Assistant Professor, Department of Pathology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Associate Professor, Department of Pathology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

出版信息

J Clin Diagn Res. 2017 May;11(5):ED32-ED33. doi: 10.7860/JCDR/2017/27968.9912. Epub 2017 May 1.

Abstract

Glomus tumour (GT) is a rare mesenchymal tumour of the stomach with Gastrointestinal Stromal Tumour (GIST), leiomyoma and schwannoma being far more common and comprising more than 90% of all gastric mesenchymal tumours. As glomus bodies are located in the peripheral parts of the human body, these tumours are peripherally located, classically the subungual region, hands, feet and trunk. While being evaluated for renal problems, a middle aged lady was incidentally found to have a gastric tumour. This was submucosal in location and was excised by a wedge resection and reported elsewhere as carcinoid tumour. The patient came to our hospital for further management. The biopsy was reviewed here and the modified diagnosis given was GT, confirmed by panel of immunohistochemistry. Two years after regular clinical follow up the patient is free of disease or any distant metastasis. In this paper the authors discuss the potential pitfalls, differential diagnoses and diagnostic clues that help in diagnosing this gastric tumour.

摘要

血管球瘤(GT)是一种罕见的胃部间叶组织肿瘤,相比之下,胃肠道间质瘤(GIST)、平滑肌瘤和神经鞘瘤更为常见,占所有胃间叶组织肿瘤的90%以上。由于血管球位于人体外周部位,这些肿瘤多位于外周,典型部位是甲下区域、手部、足部和躯干。在对一名中年女性进行肾脏问题评估时,偶然发现她患有胃部肿瘤。该肿瘤位于黏膜下层,通过楔形切除术切除,在其他地方报告为类癌肿瘤。患者前来我院进一步治疗。在此对活检进行了复查,并给出了修正诊断为血管球瘤,免疫组织化学检测小组证实了这一诊断。经过两年的定期临床随访,患者无疾病或任何远处转移。在本文中,作者讨论了有助于诊断这种胃部肿瘤的潜在陷阱、鉴别诊断和诊断线索。

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本文引用的文献

4
BRAF and KRAS mutations in sporadic glomus tumors.散发性血管球瘤中的BRAF和KRAS突变
Am J Dermatopathol. 2012 Jul;34(5):533-5. doi: 10.1097/DAD.0b013e31823931b4.
5
Cutaneous metastasis from gastric glomus tumour.胃血管球瘤皮肤转移。
Clin Exp Dermatol. 2009 Dec;34(8):e719-21. doi: 10.1111/j.1365-2230.2009.03445.x. Epub 2009 Sep 15.
6
A clinicopathologic study of glomus tumor of the stomach.
J Clin Gastroenterol. 2006 Sep;40(8):717-20. doi: 10.1097/00004836-200609000-00011.
7
Glomus tumors of the stomach.胃的血管球瘤
Cancer. 1951 Jul;4(4):726-36. doi: 10.1002/1097-0142(195107)4:4<726::aid-cncr2820040410>3.0.co;2-z.

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