在TCGA黑色素瘤数据集中鉴定与不良预后相关的细胞骨架相关和粘附相关编码区突变集。
Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome.
作者信息
Yavorski John M, Stoll Rebecca J, Samy Mohammad D, Mauro James A, Blanck George
机构信息
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; 2Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
出版信息
Curr Genomics. 2017 Jun;18(3):287-297. doi: 10.2174/1389202918666170105093953.
BACKGROUND
Relatively little cancer genome atlas data has been associated with clinically relevant stratifications of individual cancers.
RESULTS
Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma, in-cluding a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001).
CONCLUSION
Roles for CAPCR mutations in cancer progression raise a question about the potential dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein struc-tures.
背景
相对较少的癌症基因组图谱数据与个体癌症的临床相关分层相关联。
结果
确定细胞骨架相关和粘附相关蛋白质编码区域集（CAPCRs）的两个子集的突变与黑色素瘤的不良预后密切相关，包括由DSCAM、FAT3、MUC17和PCDHGC5组成的子集（p < 0.0001）。
结论
CAPCR突变在癌症进展中的作用引发了一个问题，即这些突变对多聚体亚细胞和细胞外蛋白质结构可能产生的显性负性影响。
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