Lasekan John B, Hustead Deborah S, Masor Marc, Murray Robert
Scientific & Medical Affairs, Abbott Nutrition, Abbott Laboratories, Columbus, OH, USA.
M&M Arts and Science, LLP, Durango, CO, USA.
Food Nutr Res. 2017 Jun 14;61(1):1330104. doi: 10.1080/16546628.2017.1330104. eCollection 2017.
Meta-analysis studies have documented that palm olein (PALM) predominant formulas reduce calcium and fat absorption, and bone mineralization in infants, but none have been documented for stool consistency and frequency. The study objective was to conduct a meta-analysis of published randomized clinical trials (RCTs) on the effect of PALM-based formulas on stool consistency and frequency in infants. A literature search was conducted in BIOSIS Previews®, Embase®, Embase® Alert, MEDLINE® and Cochrane databases. PALM-based RCTs with available stool outcomes were selected and meta-analyzed. Mean rank stool consistency (MRSC, primary outcome) and stool frequency (secondary outcome) were compared between infants fed PALM-based and PALM-free formulas (NoPALM), using random effects model. Nine out of identified16 studies were meta-analyzed. The mean MRSC (scale of 1 = watery to 5 = hard) in the NoPALM-fed infants was lower (softer stools) compared to the PALM-fed infants (mean difference ‒0.355, 95% Confidence Interval [CI] of ‒0.472 to ‒0.239, < 0.001). Difference for stool frequency was not significant ( = 0.613). Meta-analysis of RCTs indicated that NoPALM-fed infants have significantly softer stools but similar stool frequencies versus PALM-fed infants, despite differences in study types and design. Future meta-analysis could benefit from including comparison with human milk-fed infants.
荟萃分析研究表明，以棕榈油精（PALM）为主的配方奶粉会降低婴儿的钙和脂肪吸收以及骨矿化，但尚无关于粪便稠度和频率的相关记录。本研究的目的是对已发表的关于基于PALM的配方奶粉对婴儿粪便稠度和频率影响的随机临床试验（RCT）进行荟萃分析。在《生物学文摘数据库》（BIOSIS Previews®）、《荷兰医学文摘数据库》（Embase®）及其快讯、《医学索引数据库》（MEDLINE®）和Cochrane数据库中进行了文献检索。选取了具有可用粪便结果的基于PALM的RCT并进行荟萃分析。使用随机效应模型比较了喂养基于PALM的配方奶粉和不含PALM的配方奶粉（NoPALM）的婴儿之间的平均等级粪便稠度（MRSC，主要结果）和粪便频率（次要结果）。在确定的16项研究中，有9项进行了荟萃分析。与喂养PALM的婴儿相比，喂养NoPALM的婴儿的平均MRSC（范围为1 = 水样便至5 = 硬便）较低（粪便较软）（平均差异−0.355，95%置信区间[CI]为−0.472至−0.239，<0.001）。粪便频率差异不显著（P = 0.613）。RCT的荟萃分析表明，尽管研究类型和设计存在差异，但与喂养PALM的婴儿相比，喂养NoPALM的婴儿的粪便明显更软，但粪便频率相似。未来的荟萃分析可能会受益于纳入与母乳喂养婴儿的比较。
