Kaut Irène Kona, Abourazzak Fatima Ezzhara, Jamila Essouri, Sènami Florine Awassi, Diketa Desiré, Taoufik Harzy
Sidi Mohammeh Ben Abdellah University, Faculty of Medicine and Pharmacy, Fes, Morocco.
Department of Rheumatology, CHU Hassan II, Fes, Morocco.
Open Rheumatol J. 2017 May 31;11:53-61. doi: 10.2174/1874312901711010053. eCollection 2017.
Smoking is one of the main environmental risk factors involved in several rheumatic diseases according to ACR 2014, it is included among the risk factors for severe axial spondyloarthritis.
The objective is to study the association between smoking and the activity of the disease, the functional impact and the severity of the axial spondyloarthritis.
It is a transversal study with a descriptive and analytical aim, during the period between January 2014 and December 2015 conducted in the department of rheumatology at the CHU Hassan II of Fes. The data was recorded and analyzed using SPSS v20 univariate and bivariate analysis A value of p <0.005 has been used to identify factors associated with smoking.
The study included 214 patients, 130 men and 84 women. The mean age was 39.77 ± 13.06 (16-68) years with an average disease duration of 7.97 ± 6.4 (2-35) years. The prevalence of smoking in patients with spondyloarthritis was 36%. According to the univariate and bivariate analysis: Smoking was associated with the male sex (p≤0.0001), with a functional impairment BASFI (p = 0.038) and activity BASDAI (p=0.004) and ASDAS CRP, (p=0.036). Multivariate logistic regression analysis suggested that smoking was associated with male sex and the severity of the disease.
Our study suggests that there is a significant association between smoking and male sex and the severity of the disease.
根据美国风湿病学会（ACR）2014年的研究，吸烟是多种风湿性疾病的主要环境风险因素之一，也是重度轴性脊柱关节炎的风险因素之一。
研究吸烟与疾病活动度、功能影响以及轴性脊柱关节炎严重程度之间的关联。
这是一项具有描述性和分析性目的的横断面研究，于2014年1月至2015年12月期间在非斯哈桑二世大学医院风湿病科进行。使用SPSS v20软件记录和分析数据，采用单变量和双变量分析。p <0.005的值用于确定与吸烟相关的因素。
该研究纳入了214例患者，其中男性130例，女性84例。平均年龄为39.77±13.06（16 - 68）岁，平均病程为7.97±6.4（2 - 35）年。脊柱关节炎患者的吸烟患病率为36%。根据单变量和双变量分析：吸烟与男性性别相关（p≤0.0001），与功能障碍BASFI相关（p = 0.038）、疾病活动度BASDAI相关（p = 0.004）以及ASDAS CRP相关（p = 0.036）。多因素逻辑回归分析表明，吸烟与男性性别和疾病严重程度相关。
我们的研究表明，吸烟与男性性别以及疾病严重程度之间存在显著关联。
