Jenkins S A, Baxter J N, Corbett W A, Shields R
Br J Surg. 1985 Nov;72(11):864-7. doi: 10.1002/bjs.1800721105.
The effects of a somatostatin analogue, SMS 201-995 on hepatic haemodynamics were studied in rats with dimethylnitrosamine-induced cirrhosis. An intravenous infusion of 1, 2 or 4 micrograms kg-1 body wt h-1 SMS 201-995 produced a rapid and sustained decrease in portal pressure, portal venous flow and liver blood flow without significantly altering arterial blood pressure or pulse. The reductions in portal pressure, portal venous flow and liver blood were accompanied by an increase in splanchnic vascular resistance. Portal venous resistance was not affected. Subcutaneous injection of 2 micrograms kg-1 body wt SMS 201-995 produced a gradual decrease in portal pressure, the maximum reduction occurring 18 min after administration. This reduction in portal pressure was sustained for a further 20 min. The results suggest that SMS 201-995 may be of value in the control of bleeding oesophageal varices. Furthermore, the prolonged duration of action of SMS 201-995 following its subcutaneous administration suggests that the analogue may be useful in the long-term management of portal hypertension in patients with cirrhosis.
在二甲基亚硝胺诱导的肝硬化大鼠中研究了生长抑素类似物SMS 201-995对肝脏血流动力学的影响。静脉输注1、2或4微克/千克体重·小时的SMS 201-995可使门静脉压力、门静脉血流量和肝脏血流量迅速且持续降低，而不会显著改变动脉血压或脉搏。门静脉压力、门静脉血流量和肝脏血流量的降低伴随着内脏血管阻力的增加。门静脉阻力未受影响。皮下注射2微克/千克体重的SMS 201-995可使门静脉压力逐渐降低，给药后18分钟出现最大降幅。门静脉压力的这种降低持续了另外20分钟。结果表明，SMS 201-995可能在控制食管静脉曲张出血方面具有价值。此外，SMS 201-995皮下给药后作用时间延长表明该类似物可能对肝硬化患者门静脉高压的长期管理有用。
