Jenkins S A, Baxter J N, Corbett W A, Shields R
Br J Surg. 1985 Dec;72(12):1009-12. doi: 10.1002/bjs.1800721225.
The effects of a somatostatin analogue, SMS 201-995, on hepatic haemodynamics in the pig and on intravariceal pressure in man were studied. An infusion of 250 micrograms/h SMS 201-995 significantly reduced portal pressure, portal venous flow and hepatic artery flow in the pig. These changes in hepatic haemodynamics were accompanied by a reduction in cardiac output, a reflex slowing of the heart and an increase in arterial blood pressure. Splanchnic vascular resistance was increased following SMS 201-995 administration but hepatic vascular resistance remained unchanged. Administration of 50 micrograms SMS 201-995 reduced the intravariceal pressure from 27.4 +/- 2.5 to 15.8 +/- 2.1 mmHg in 9 patients with cirrhosis and portal hypertension. Administration of 50 micrograms SMS 201-995 also reduced portal pressure from 29 to 22 mmHg in a patient undergoing an elective portacaval shunt. These results suggest that SMS 201-995 may be of value in the control of bleeding oesophageal varices. Furthermore, because of its prolonged duration of action SMS 201-995 may be useful in the long term management of portal hypertension in patients with cirrhosis.
研究了生长抑素类似物SMS 201-995对猪肝脏血流动力学及人曲张静脉内压力的影响。以250微克/小时的速度输注SMS 201-995可显著降低猪的门静脉压力、门静脉血流量和肝动脉血流量。肝脏血流动力学的这些变化伴随着心输出量减少、心脏反射性减慢及动脉血压升高。给予SMS 201-995后内脏血管阻力增加，但肝血管阻力保持不变。对于9例肝硬化和门静脉高压患者，给予50微克SMS 201-995可使曲张静脉内压力从27.4±2.5毫米汞柱降至15.8±2.1毫米汞柱。对于一名接受择期门腔分流术的患者，给予50微克SMS 201-995也可使门静脉压力从29毫米汞柱降至22毫米汞柱。这些结果表明，SMS 201-995可能在控制食管静脉曲张出血方面具有价值。此外，由于其作用持续时间长，SMS 201-995可能对肝硬化患者门静脉高压的长期管理有用。
