van Pinxteren P C, van Alphen G W
Curr Eye Res. 1985 Sep;4(9):989-93. doi: 10.3109/02713689509000006.
Selective and non-selective adrenergic drugs were given to isolated extraocular rectus muscles (EOM) of rabbits to differentiate its postjunctional adrenergic receptors. Without precontraction none of the adrenergic agents had significant effects, but after cholinergic precontraction of the muscles a further contraction could be obtained with the non-selective agonists epinephrine, norepinephrine and isoproterenol, with the alpha 2-agonist B-HT 920, and with the beta 2-agonist terbutaline. No effect was seen from alpha 1- and beta 1-agonists. The presence of alpha 2- and beta 2-receptors was confirmed in experiments with selective and non-selective adrenergic antagonists. The lack of alpha 1-receptors in EOM and the absence of a hypertensive peak after topical alpha 2- and beta 2-agonists in vivo does not support the assumption that the initial rise in intraocular pressure (IOP) after topical epinephrine is produced by contraction of EOM.
给家兔离体眼外直肌（EOM）注射选择性和非选择性肾上腺素能药物，以区分其节后肾上腺素能受体。在未预先收缩的情况下，没有一种肾上腺素能药物有显著作用，但在肌肉进行胆碱能预收缩后，非选择性激动剂肾上腺素、去甲肾上腺素和异丙肾上腺素、α₂激动剂B-HT 920以及β₂激动剂特布他林均可使肌肉进一步收缩。α₁和β₁激动剂则未见效果。在使用选择性和非选择性肾上腺素能拮抗剂的实验中证实了α₂和β₂受体的存在。眼外直肌中缺乏α₁受体以及体内局部应用α₂和β₂激动剂后未出现高血压峰值，这并不支持局部应用肾上腺素后眼内压（IOP）最初升高是由眼外直肌收缩所致的假设。
