Dickinson R J, King A, Wight D G, Hunter J O, Neale G
Dis Colon Rectum. 1985 Dec;28(12):929-30. doi: 10.1007/BF02554309.
The efficacy of continuous and "on-demand" sulfasalazine in the maintenance of remission of ulcerative colitis was tested in a randomized trial. Patients were reviewed at four monthly intervals for one year. Twenty-eight patients completed the trial. Ten took continuous sulfasalazine and three relapsed, while 18 took "on-demand" sulfasalazine and seven relapsed (N.S.). Rectal biopsies from each patient group were compared at each attendance, and no significant difference in histologic score was found. It is concluded that "on-demand" sulfasalazine may be as effective as continuous sulfasalazine in the maintenance of remission of ulcerative colitis.
在一项随机试验中，对连续服用和“按需”服用柳氮磺胺吡啶在维持溃疡性结肠炎缓解方面的疗效进行了测试。患者每四个月接受一次为期一年的复查。28名患者完成了试验。10名患者连续服用柳氮磺胺吡啶，3人复发；而18名患者“按需”服用柳氮磺胺吡啶，7人复发（无显著差异）。每次复诊时对每组患者的直肠活检结果进行比较，未发现组织学评分有显著差异。得出的结论是，“按需”服用柳氮磺胺吡啶在维持溃疡性结肠炎缓解方面可能与连续服用柳氮磺胺吡啶同样有效。
