Jończyk-Skórka Katarzyna, Kowalski Jan
Polish Mother's Memorial Hospital - Research Institute in Lodz, Poland.
Department of Internal Diseases and Cardiac Rehabilitation, Medical University of Lodz, Poland.
Pol Merkur Lekarski. 2017 Jun 23;42(252):241-246.
The aim of the study was to assess risk factors for glucose metabolism disorders.
The study involved 197 people, 92 women and 105 men aged 63.21±8.74 years. In order to assess glucose metabolism disorders, patients were divided into three groups. The first group (DM) consisted of 60 people (16 women and 44 men aged 61.92±8.46 years). These were people with type 2 diabetes. Second group (IFG IGT) consisted of 67 people (35 women and 32 men aged 65±8.5 years). These were people who were diagnosed with impaired fasting glucose or impaired glucose tolerance. The third group, the control one (K) consisted of 70 people (41 women and 29 men aged 62.6±9.06 years). They were healthy individuals. Age, BMI, blood pressure, heart rate, pulse pressure, lipids in the blood serum, serum creatinine, glomerular filtration rate (GFR), the number of pack-years were assessed. Each patient responded to diabetes risk questionnaire.
Univariate analyzes showed statistically significant differences between groups due to: systolic blood pressure, heart rate, pulse pressure, total cholesterol, LDL cholesterol, HDL cholesterol, the number of points obtained in diabetes risk questionnaire, serum creatinine and GFR. Multivariate analyzes demonstrated that in IFG IGT group independent risk factors that increased the risk of prediabetes were elevated levels of total cholesterol (OR 1,945, 95%CI [1,195-3,166], p=0,007) and the result of the diabetes risk questionnaire (OR 1,191, 95%CI [1,061-1,337], p=0,003). In diabetes mellitus (DM) group independent risk factors that increased the risk of diabetes were pulse pressure (OR 1,123, 95%CI [1,063-1,188], p<0,001) and the result of the diabetes risk questionnaire. Independent risk factor that lowered the risk of diabetes (OR 0,068, 95%CI [0,018-0,251], p<0,001) and prediabetes (OR 0,324, 95%CI [0,109-0,969], p=0,044) was higher serum HDL cholesterol.
Elevated level of total cholesterol and the result of the diabetes risk questionnaire are independent risk factors that increase the risk of prediabetes. Puls pressure and the result of the diabetes risk questionnaire are independent risk factors that increase the risk of diabetes. Independent risk factor that lowers the risk of glucose metabolism disorders is higher serum HDL cholesterol.
本研究旨在评估糖代谢紊乱的危险因素。
本研究纳入了197人，其中92名女性和105名男性，年龄为63.21±8.74岁。为了评估糖代谢紊乱情况，将患者分为三组。第一组（DM）由60人组成（16名女性和44名男性，年龄为61.92±8.46岁）。这些是2型糖尿病患者。第二组（IFG IGT）由67人组成（35名女性和32名男性，年龄为65±8.5岁）。这些是被诊断为空腹血糖受损或糖耐量受损的人。第三组，即对照组（K）由70人组成（41名女性和29名男性，年龄为62.6±9.06岁）。他们是健康个体。评估了年龄、体重指数、血压、心率、脉压、血清脂质、血清肌酐、肾小球滤过率（GFR）、吸烟包年数。每位患者都回答了糖尿病风险问卷。
单因素分析显示，由于收缩压、心率、脉压、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、糖尿病风险问卷得分、血清肌酐和GFR，各组之间存在统计学显著差异。多因素分析表明，在IFG IGT组中，增加糖尿病前期风险的独立危险因素是总胆固醇水平升高（OR 1.945，95%CI[1.195 - 3.166]，p = 0.007）和糖尿病风险问卷结果（OR 1.191，95%CI[1.061 - 1.337]，p = 0.003）。在糖尿病（DM）组中，增加糖尿病风险的独立危险因素是脉压（OR 1.123，95%CI[1.063 - 1.188]，p < 0.001）和糖尿病风险问卷结果。降低糖尿病风险（OR 0.068，95%CI[0.018 - 0.251]，p < 0.001）和糖尿病前期风险（OR 0.324，95%CI[0.109 - 0.969]，p = 0.044）的独立危险因素是较高的血清高密度脂蛋白胆固醇。
总胆固醇水平升高和糖尿病风险问卷结果是增加糖尿病前期风险的独立危险因素。脉压和糖尿病风险问卷结果是增加糖尿病风险的独立危险因素。降低糖代谢紊乱风险的独立危险因素是较高的血清高密度脂蛋白胆固醇。
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