Sinnott Margaret, Kinsley Brendan T, Jackson Abaigeal D, Walsh Cathal, O'Grady Tony, Nolan John J, Gaffney Peter, Boran Gerard, Kelleher Cecily, Carr Bernadette
Vhi Healthcare Ltd, Dublin, Republic of Ireland.
Mater Misericordiae University Hospital, Dublin, Republic of Ireland.
PLoS One. 2015 Apr 15;10(4):e0122704. doi: 10.1371/journal.pone.0122704. eCollection 2015.
Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective longitudinal cohort study on the prevalence of undiagnosed Type 2 diabetes and prediabetes, diabetes risk and cardiovascular risk in a cohort of Irish adults aged 45-75 years.
Members of the largest Irish private health insurance provider aged 45 to 75 years were invited to participate in the study.
already diagnosed with diabetes or taking oral hypoglycaemic agents. Participants completed a detailed medical questionnaire, had weight, height, waist and hip circumference and blood pressure measured. Fasting blood samples were taken for fasting plasma glucose (FPG). Those with FPG in the impaired fasting glucose (IFG) range had a 75gm oral glucose tolerance test performed.
122,531 subjects were invited to participate. 29,144 (24%) completed the study. The prevalence of undiagnosed diabetes was 1.8%, of impaired fasting glucose (IFG) was 7.1% and of impaired glucose tolerance (IGT) was 2.9%. Dysglycaemia increased among those aged 45-54, 55-64 and 65-75 years in both males (10.6%, 18.5%, 21.7% respectively) and females (4.3%, 8.6%, 10.9% respectively). Undiagnosed T2D, IFG and IGT were all associated with gender, age, blood pressure, BMI, abdominal obesity, family history of diabetes and triglyceride levels. Using FPG as initial screening may underestimate the prevalence of T2D in the study population.
This study is the largest screening study for diabetes and prediabetes in the Irish population. Follow up of this cohort will provide data on progression to diabetes and on cardiovascular outcomes.
2型糖尿病有很长的临床前期无症状阶段。早期检测可能会延缓或阻止疾病进展。糖尿病与血管健康倡议（DMVhi）作为一项前瞻性纵向队列研究启动，旨在研究爱尔兰45 - 75岁成年人队列中未诊断的2型糖尿病和糖尿病前期的患病率、糖尿病风险和心血管风险。
邀请爱尔兰最大的私人健康保险提供商中年龄在45至75岁的成员参与研究。
已被诊断患有糖尿病或正在服用口服降糖药。参与者完成一份详细的医学问卷，并测量体重、身高、腰围和臀围以及血压。采集空腹血样以检测空腹血糖（FPG）。空腹血糖处于空腹血糖受损（IFG）范围的参与者进行75克口服葡萄糖耐量试验。
邀请了122,531名受试者参与。29,144名（24%）完成了研究。未诊断糖尿病的患病率为1.8%，空腹血糖受损（IFG）的患病率为7.1%，糖耐量受损（IGT）的患病率为2.9%。45 - 54岁、55 - 64岁和65 - 75岁的男性（分别为10.6%、18.5%、21.7%）和女性（分别为4.3%、8.6%、10.9%）中血糖异常情况均有所增加。未诊断的2型糖尿病、IFG和IGT均与性别、年龄、血压、体重指数、腹部肥胖、糖尿病家族史和甘油三酯水平相关。使用FPG作为初始筛查可能会低估研究人群中2型糖尿病的患病率。
本研究是爱尔兰人群中针对糖尿病和糖尿病前期的最大规模筛查研究。对该队列的随访将提供有关糖尿病进展和心血管结局的数据。
