Yamazaki M, Arai A
J Pharmacobiodyn. 1985 Jul;8(7):513-7. doi: 10.1248/bpb1978.8.513.
The administration of matrine, which has antiulcerogenic activity against stress ulcer, exhibited clear contraction on the preparation of the fundus strip of rats at high concentration (from 2 X 10(-4) g/ml). The contractile response of the fundus strip to matrine was not inhibited by treatment with tetrodotoxin, and was not modified with atropine at 10(-4) g/ml, while pretreatment of the fundus strip with antihistamines abolished or reduced the contractile response. The maximum contractile response of the fundus strip was not altered significantly by pretreatment of the rat with indomethacin.
具有抗应激性溃疡活性的苦参碱，在高浓度（2×10⁻⁴ g/ml起）时对大鼠胃底肌条标本呈现明显收缩作用。胃底肌条对苦参碱的收缩反应不受河豚毒素处理的抑制，在10⁻⁴ g/ml时也不受阿托品的影响，而用抗组胺药预处理胃底肌条则可消除或减弱收缩反应。用吲哚美辛预处理大鼠后，胃底肌条的最大收缩反应无明显改变。
