Brown Ian S, Miller Gregory C
Envoi Specialist Pathologists, Brisbane, Australia.
Envoi Specialist Pathologists, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Qld, Australia.
Pathology. 2017 Aug;49(5):476-478. doi: 10.1016/j.pathol.2017.05.006. Epub 2017 Jun 26.
Brunner's gland cysts are rare, benign lesions of the duodenum usually seen as incidental, polypoid or cystic lesions of the duodenum. We present a series of 25 cases of Brunner's gland cyst, the largest case series to date. All the cases were identified during endoscopic assessment for unrelated causes. The mean age of the patients was 66.2 years and the sex ratio was approximately equal. Most were detected as a small (3-10 mm) polypoid lesion in the second part of the duodenum, away from the ampulla. Most of the cysts were unilocular and all were lined by undulating, cytologically bland cuboidal to columnar cells with clear cytoplasm and small, basal nuclei. No mitotic activity or proliferative activity was seen. No recurrence was noted, despite incomplete removal in many cases. We agree with the hypothesis that Brunner's gland cysts are likely to be caused by local obstruction to the draining duct of Brunner's glands.
布伦纳腺囊肿是十二指肠罕见的良性病变，通常表现为十二指肠偶然发现的息肉样或囊性病变。我们报告了一系列25例布伦纳腺囊肿病例，这是迄今为止最大的病例系列。所有病例均在内镜检查中因无关原因而被发现。患者的平均年龄为66.2岁，性别比例大致相等。大多数病例表现为十二指肠第二部距壶腹较远部位的小（3 - 10毫米）息肉样病变。大多数囊肿为单房性，囊壁均由起伏不平、细胞学表现温和的立方形至柱状细胞衬覆，胞质清亮，细胞核小且位于基底部。未见有丝分裂活动或增殖活性。尽管许多病例切除不完全，但未观察到复发情况。我们赞同布伦纳腺囊肿可能是由布伦纳腺排泄管局部阻塞所致这一假说。
