Current knowledge on alleviating infections through the use of some commonly known natural products: bench to bedside.

, a spiral-shaped Gram-negative bacterium, has been classified as a class I carcinogen by the World Health Organization and recognized as the causative agent for peptic ulcers, duodenal ulcer, gastritis, mucosa-associated lymphoid tissue lymphomas, and gastric cancer. Owing to their alarming rate of drug resistance, eradication of remains a global challenge. Triple therapy consisting of a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole, is generally the recommended standard for the treatment of infection. Complementary and alternative medicines have a long history in the treatment of gastrointestinal ailments and various compounds has been tested for anti- activity both and ; however, their successful use in human clinical trials is sporadic. Hence, the aim of this review is to analyze the role of some well-known natural products that have been tested in clinical trials in preventing, altering, or treating infections. Whereas some and studies in the literature have demonstrated the successful use of a few potential natural products for the treatment of -related infections, others indicate a need to consider natural products, with or without triple therapy, as a useful alternative in treating -related infections. Thus, the reported mechanisms include killing of urease inhibition, induction of bacterial cell damage, and immunomodulatory effect on the host immune system. Furthermore, both and studies have demonstrated the successful use of some potential natural products for the treatment of -related infections. Nevertheless, the routine prescription of potential complementary and alternative medicines continues to be restrained, and evidence on the safety and efficacy of the active compounds remains a subject of ongoing debate.