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药物研发失败时代的整合方法。

Integrative approach in the era of failing drug discovery and development.

作者信息

Earm Keehyun, Earm Yung E

机构信息

Research Department, Korea Finance Corporation, Seoul, Korea.

Department of Physiology, College of Medicine, Seoul National University, Seoul, Korea.

出版信息

Integr Med Res. 2014 Dec;3(4):211-216. doi: 10.1016/j.imr.2014.09.002. Epub 2014 Sep 10.

DOI:10.1016/j.imr.2014.09.002
PMID:28664100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5481768/
Abstract

The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many successes, a postreductionism method, which is systems biology, is on the rise. In this review, we discuss the foundations of two distinct approaches in finding a new drug.

摘要

药物研发效率的下降主要由两个因素导致

监管障碍增多以及容易解决的问题已全部得到解决。此外，近来基于靶点的方法被认为正在提高创新的成本。尽管基于靶点的方法取得了许多成功，但一种后还原论方法——系统生物学正在兴起。在本综述中，我们讨论了寻找新药的两种不同方法的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffdb/5481768/13f055616e1d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffdb/5481768/13f055616e1d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffdb/5481768/13f055616e1d/gr1.jpg

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