Faculty of Medicine, Institute of Medical Microbiology, Semmelweis University, Nagyvarad ter 4, 1089, Budapest, Hungary.
OLPE, LLC, 801 Mockingbird Lane, Audubon, PA, 19403, USA.
Amino Acids. 2017 Sep;49(9):1647-1651. doi: 10.1007/s00726-017-2457-7. Epub 2017 Jun 29.
Host defense peptides are preferably administered as topical therapeutic agents. We have investigated whether peptide A3-APO can enter the circulation when applied to the ear skin. Efficacy of peptide monotherapy as transdermal administration option was assessed in a systemic mouse Acinetobacter baumannii model. A3-APO reduced mortality and demonstrated a statistically significant reduction of blood bacterial counts, regardless whether it was administered prior or after bacterial challenge. The peptidic metabolite of A3-APO was efficacious when applied to the ear or tail.
宿主防御肽最好作为局部治疗药物给药。我们研究了将肽 A3-APO 施用于耳部皮肤时是否可以进入循环。在全身性小鼠鲍曼不动杆菌模型中评估了肽单药治疗作为透皮给药选择的疗效。A3-APO 降低了死亡率，并显示出血液细菌计数的统计学显著降低，无论其在细菌攻击之前还是之后给药。A3-APO 的肽代谢物在耳部或尾部给药时有效。
