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本文引用的文献

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Amino Acids. 2017 Sep;49(9):1647-1651. doi: 10.1007/s00726-017-2457-7. Epub 2017 Jun 29.
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Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications.产气荚膜梭菌肠毒素：作用、遗传学及转化应用
Toxins (Basel). 2016 Mar 16;8(3):73. doi: 10.3390/toxins8030073.
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Pharmacokinetics and in vivo efficacy of optimized oncocin derivatives.优化后的癌抑素衍生物的药代动力学及体内疗效
J Antimicrob Chemother. 2016 Apr;71(4):1003-11. doi: 10.1093/jac/dkv454. Epub 2016 Jan 31.
4
Short Proline-Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit.富含脯氨酸的短抗菌肽可抑制细菌70S核糖体或其大亚基50S的组装。
Chembiochem. 2015 Nov 2;16(16):2304-8. doi: 10.1002/cbic.201500375. Epub 2015 Oct 8.
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Antimicrobial Peptides in Human Sepsis.人类脓毒症中的抗菌肽
Front Immunol. 2015 Aug 20;6:404. doi: 10.3389/fimmu.2015.00404. eCollection 2015.
6
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7
Combinations of β-lactam or aminoglycoside antibiotics with plectasin are synergistic against methicillin-sensitive and methicillin-resistant Staphylococcus aureus.β-内酰胺类或氨基糖苷类抗生素与plectasin联合使用对甲氧西林敏感和耐甲氧西林金黄色葡萄球菌具有协同作用。
PLoS One. 2015 Feb 18;10(2):e0117664. doi: 10.1371/journal.pone.0117664. eCollection 2015.
8
Current challenges in peptide-based drug discovery.基于肽的药物研发中的当前挑战。
Front Chem. 2014 Aug 8;2:62. doi: 10.3389/fchem.2014.00062. eCollection 2014.
9
A small peptide with potential ability to promote wound healing.一种具有促进伤口愈合潜在能力的小肽。
PLoS One. 2014 Mar 19;9(3):e92082. doi: 10.1371/journal.pone.0092082. eCollection 2014.
10
Therapeutic potential of the antimicrobial peptide OH-CATH30 for antibiotic-resistant Pseudomonas aeruginosa keratitis.抗菌肽OH-CATH30对耐抗生素铜绿假单胞菌性角膜炎的治疗潜力。
Antimicrob Agents Chemother. 2014 Jun;58(6):3144-50. doi: 10.1128/AAC.00095-14. Epub 2014 Mar 17.

误入歧途

Racing on the Wrong Track.

作者信息

Otvos Laszlo

机构信息

Institute of Medical Microbiology, Semmelweis UniversityBudapest, Hungary.

OLPE, LLCAudubon, PA, United States.

出版信息

Front Chem. 2017 Jun 19;5:42. doi: 10.3389/fchem.2017.00042. eCollection 2017.

DOI:10.3389/fchem.2017.00042
PMID:28674690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5475397/
Abstract

The preclinical and benchmark figures of cationic antimicrobial peptides have to be revisited based on the newly discovered alternative modes of action.

摘要

基于新发现的替代作用模式，阳离子抗菌肽的临床前和基准数据必须重新审视。