Jones Mark R, Hadley Graham R, Kaye Alan D, Lirk Philipp, Urman Richard D
Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University, New York, NY, 10016, USA.
Curr Pain Headache Rep. 2017 Aug;21(8):35. doi: 10.1007/s11916-017-0637-5.
Breast surgery, performed for medical or cosmetic reasons, remains one of the most frequently performed procedures, with over 500,000 cases performed annually in the USA alone. Historically, general anesthesia (GA) has been widely accepted as the gold-standard technique, while epidural anesthesia was largely considered too invasive and thus unnecessary for breast surgery. Over the past years, paravertebral block (PVB) has emerged as an alternative analgesic or even anesthetic technique. Substantial evidence supports the use of PVB for major breast surgery.
In patients receiving PVB, immediate and long-term analgesia is superior to systemic analgesia while opioid use and typical adverse effects of systemic analgesia such as nausea and vomiting are decreased. The benefits may also include an improved oncological survival with PVB after mastectomy for malignancy. PVB offers clinically significant benefits for perioperative care of patients undergoing breast surgery. The benefits of continuous PVB are most firmly supported for major breast surgery and include both effective short-term pain control and reduction in burden of chronic pain. On the other hand, minor breast surgery should be effectively manageable using multimodal analgesia in the majority of patients, with PVB reserved as analgesic rescue or for patients at high risk of excessive perioperative pain.
出于医疗或美容目的进行的乳房手术仍然是最常开展的手术之一,仅在美国每年就有超过50万例。从历史上看,全身麻醉(GA)一直被广泛接受为金标准技术,而硬膜外麻醉在很大程度上被认为侵入性过大,因此对于乳房手术来说没有必要。在过去几年中,椎旁阻滞(PVB)已成为一种替代镇痛甚至麻醉技术。大量证据支持在主要乳房手术中使用PVB。
在接受PVB的患者中,即时和长期镇痛效果优于全身镇痛,同时阿片类药物的使用以及全身镇痛的典型不良反应如恶心和呕吐减少。其益处还可能包括恶性肿瘤乳房切除术后使用PVB可改善肿瘤学生存率。PVB为接受乳房手术的患者围手术期护理提供了具有临床意义的益处。持续PVB的益处对于主要乳房手术得到了最有力的支持,包括有效的短期疼痛控制和减轻慢性疼痛负担。另一方面,大多数患者通过多模式镇痛应能有效应对小型乳房手术,PVB则留作镇痛补救措施或用于围手术期疼痛过度风险高的患者。