Pelletier Jonathan H, Nagaraj Shashi, Gbadegesin Rasheed, Wigfall Delbert, McGann Kathleen A, Foreman John
Department of Pediatrics, Duke University Health System, Durham, NC, USA.
Division of Pediatric Nephrology, Department of Pediatrics, Duke University Health System, Durham, NC, USA.
Pediatr Transplant. 2017 Sep;21(6). doi: 10.1111/petr.13022. Epub 2017 Jun 30.
NE (typhlitis) is a potentially life-threatening disease process characterized by bowel wall edema, ulceration, and hemorrhage in an immunosuppressed patient. We report a 15-year-old boy status post deceased donor renal transplantation who presented with fever, abdominal pain, and diarrhea. Laboratory studies revealed neutropenia 5 days prior to admission, and abdominal computed tomography revealed bowel wall thickening in the cecum consistent with NE. He was treated with piperacillin-tazobactam and gentamicin and recovered. To our knowledge, this is the first report of a case of NE in a pediatric kidney transplant recipient.
中性粒细胞减少性小肠结肠炎(NE)是一种潜在的危及生命的疾病过程,其特征为免疫抑制患者出现肠壁水肿、溃疡和出血。我们报告一例15岁男性,在接受已故供体肾移植术后,出现发热、腹痛和腹泻。实验室检查显示入院前5天出现中性粒细胞减少,腹部计算机断层扫描显示盲肠肠壁增厚,符合中性粒细胞减少性小肠结肠炎表现。患者接受哌拉西林-他唑巴坦和庆大霉素治疗后康复。据我们所知,这是小儿肾移植受者中中性粒细胞减少性小肠结肠炎病例的首例报告。