Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
J Diabetes Investig. 2018 Mar;9(2):411-418. doi: 10.1111/jdi.12708. Epub 2017 Aug 3.
AIMS/INTRODUCTION: The present study evaluated the ability of lipid accumulation product (LAP), visceral adiposity index (VAI), and the product of triglycerides and glucose (TyG), three novel markers, in identifying metabolic syndrome (MetS) with different criteria in middle-aged and elderly Chinese.
During June 2012 to January 2013, 992 consecutive patients (age ≥40 years) were enrolled at Daping Hospital. The criteria of MetS were based on the International Diabetes Federation and the modified National Cholesterol Education Program's Adult Treatment Panel III. VAI, LAP and TyG were computed based on a published mathematical model.
The prevalence of MetS was 42.8%. The receiver operating characteristic curve found LAP, VAI and TyG were positively related to MetS in both criteria. The optimal cut-offs of VAI, LAP and TyG for the modified National Cholesterol Education Program's Adult Treatment Panel III and International Diabetes Federation criteria were 2.015, 31.465 and 8.706, and 2.035, 37.99 and 8.697, respectively. After adjustment of potential confounding factors, VAI, LAP and TyG were significantly correlated with MetS in all criteria according to optimal cut-offs. For MetS, reliable predictive value was observed in different subgroups (age and sex). LAP showed the greatest area under the curve in MetS with the International Diabetes Federation definition (area under the curve 0.887, 95% confidence interval 0.852-0.922).
AP, VAI and TyG were reliable surrogate markers for identifying MetS in middle-aged and elderly Chinese. LAP could be a better parameter than VAI and TyG for predicting MetS in the present study.
目的/引言：本研究评估了三种新的标志物——脂联素（LAP）、内脏脂肪指数（VAI）和甘油三酯与葡萄糖的乘积（TyG）——在识别中年和老年中国人不同标准下的代谢综合征（MetS）方面的能力。
2012 年 6 月至 2013 年 1 月，连续招募了 992 名（年龄≥40 岁）在大坪医院就诊的患者。MetS 的标准基于国际糖尿病联合会和改良的美国国家胆固醇教育计划成人治疗专家组 III。VAI、LAP 和 TyG 是根据已发表的数学模型计算得出的。
MetS 的患病率为 42.8%。受试者工作特征曲线发现，在两种标准下，LAP、VAI 和 TyG 与 MetS 呈正相关。改良的美国国家胆固醇教育计划成人治疗专家组 III 和国际糖尿病联合会标准的 VAI、LAP 和 TyG 的最佳截断值分别为 2.015、31.465 和 8.706，以及 2.035、37.99 和 8.697。在调整了潜在的混杂因素后，根据最佳截断值，VAI、LAP 和 TyG 在所有标准下与 MetS 均显著相关。对于 MetS，在不同亚组（年龄和性别）中均观察到可靠的预测值。在使用国际糖尿病联合会定义时，LAP 在 MetS 中的曲线下面积最大（曲线下面积 0.887，95%置信区间 0.852-0.922）。
LAP、VAI 和 TyG 是识别中年和老年中国人 MetS 的可靠替代标志物。在本研究中，LAP 可能是比 VAI 和 TyG 更好的预测 MetS 的参数。
