Lee Seung-Hwan, Kwon Hyuk-Sang, Park Yong-Moon, Ha Hee-Sung, Jeong Seung Hee, Yang Hae Kyung, Lee Jin-Hee, Yim Hyeon-Woo, Kang Moo-Il, Lee Won-Chul, Son Ho-Young, Yoon Kun-Ho
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, Seoul, Korea.
PLoS One. 2014 Feb 28;9(2):e90430. doi: 10.1371/journal.pone.0090430. eCollection 2014.
To determine whether the TyG index, a product of the levels of triglycerides and fasting plasma glucose (FPG) might be a valuable marker for predicting future diabetes.
A total of 5,354 nondiabetic subjects who had completed their follow-up visit for evaluating diabetes status were selected from a large cohort of middle-aged Koreans in the Chungju Metabolic Disease Cohort study. The risk of diabetes was assessed according to the baseline TyG index, calculated as ln[fasting triglycerides (mg/dL) × FPG (mg/dL)/2]. The median follow-up period was 4.6 years.
During the follow-up period, 420 subjects (7.8%) developed diabetes. The baseline values of the TyG index were significantly higher in these subjects compared with nondiabetic subjects (8.9 ± 0.6 vs. 8.6 ± 0.6; P<0.0001) and the incidence of diabetes increased in proportion to TyG index quartiles. After adjusting for age, gender, body mass index, waist circumference, systolic blood pressure, high-density lipoprotein (HDL)-cholesterol level, a family history of diabetes, smoking, alcohol drinking, education level and serum insulin level, the risk of diabetes onset was more than fourfold higher in the highest vs. the lowest quartile of the TyG index (relative risk, 4.095; 95% CI, 2.701-6.207). The predictive power of the TyG index was better than the triglyceride/HDL-cholesterol ratio or the homeostasis model assessment of insulin resistance.
The TyG index, a simple measure reflecting insulin resistance, might be useful in identifying individuals at high risk of developing diabetes.
确定甘油三酯水平与空腹血糖（FPG）的乘积——TyG指数是否可能是预测未来糖尿病的一个有价值的标志物。
从忠州代谢疾病队列研究中的一大群中年韩国人中选取了5354名完成糖尿病状态评估随访的非糖尿病受试者。根据基线TyG指数评估糖尿病风险，该指数计算为ln[空腹甘油三酯（mg/dL）×FPG（mg/dL）/2]。中位随访期为4.6年。
在随访期间，420名受试者（7.8%）患糖尿病。与非糖尿病受试者相比，这些受试者的TyG指数基线值显著更高（8.9±0.6对8.6±0.6；P<0.0001），且糖尿病发病率随TyG指数四分位数增加。在调整年龄、性别、体重指数、腰围、收缩压、高密度脂蛋白（HDL）胆固醇水平、糖尿病家族史、吸烟、饮酒、教育水平和血清胰岛素水平后，TyG指数最高四分位数组与最低四分位数组相比，糖尿病发病风险高出四倍多（相对风险，4.095；95%可信区间，2.701 - 6.207）。TyG指数的预测能力优于甘油三酯/HDL胆固醇比值或胰岛素抵抗的稳态模型评估。
TyG指数是一种反映胰岛素抵抗的简单指标，可能有助于识别糖尿病高危个体。
