Wiesenfeld-Hallin Z
Neurosci Lett. 1985 Nov 20;62(1):69-74. doi: 10.1016/0304-3940(85)90286-1.
Using behavioral and electrophysiological techniques, evidence was obtained that somatostatin (SOM) has an excitatory role in spinal sensory and reflex mechanisms of the rat. Intrathecal (i.t.) SOM (1 and 10 micrograms) induced a dose-dependent caudally directed scratching behavior lasting about 20 min. In decerebrated, spinalized, unanesthetized rats, small doses of i.t. SOM (10 ng-1 micrograms) increased the excitability of the hamstring flexion reflex. Similar effects on the reflex may be seen after conditioning afferent C-fiber activation. The results indicate that during C-afferent activity SOM may be released and may increase spinal cord excitability.
运用行为学和电生理学技术，已获得证据表明生长抑素（SOM）在大鼠脊髓感觉和反射机制中具有兴奋作用。鞘内注射（i.t.）SOM（1微克和10微克）可诱发剂量依赖性的尾部搔抓行为，持续约20分钟。在去大脑、脊髓横断、未麻醉的大鼠中，小剂量鞘内注射SOM（10纳克 - 1微克）可增强绳肌屈曲反射的兴奋性。在传入C纤维激活进行条件化后，对该反射也可观察到类似效应。结果表明，在C传入纤维活动期间，SOM可能会释放并可能增加脊髓兴奋性。
