Emiroglu Nazan, Yıldız Pelin, Biyik Ozkaya Dilek, Bahalı Anıl Gulsel, Su Ozlem, Onsun Nahide
Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey.
Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey.
Pediatr Dermatol. 2017 Jul;34(4):438-445. doi: 10.1111/pde.13184. Epub 2017 Jun 30.
BACKGROUND/OBJECTIVES: Spitz nevi are melanocytic lesions with clinical, dermoscopic, and histopathologic presentations that may resemble those of melanoma. The evolution of Spitz nevi is a well-known feature. The objectives of this study were to investigate the clinical and dermoscopic features of Spitz nevi and define their evolution.
A retrospective observational study was performed and 70 Spitz nevi were analyzed using clinical and dermoscopic examination.
Seventy patients were included in the study. The most common dermoscopic pattern was globular (n = 35 [50%]) followed by starburst (n = 24 [34.3%]), reticular (n = 8 [11.4%]), and homogeneous (n = 3 [4.3%]). Follow-up data were available for 27 of 70 patients. Of these, 21 demonstrated evolution on the follow-up images. A stable pattern (no evolution) was noted in 6 of 27 lesions. The patients who exhibited evolution were younger on average than the stable group (p = 0.04).
Based on our study, the most common biologic behavior for Spitz nevi is evolution. Although no significant differences were observed in other clinical features, the inverse relationship between evolution and age is important to consider when attempting to differentiate Spitz nevus from melanoma.
背景/目的：Spitz痣是一种黑素细胞性病变，其临床、皮肤镜及组织病理学表现可能与黑色素瘤相似。Spitz痣的演变是一个众所周知的特征。本研究的目的是调查Spitz痣的临床和皮肤镜特征，并明确其演变情况。
进行了一项回顾性观察研究，对70例Spitz痣进行了临床和皮肤镜检查分析。
70例患者纳入研究。最常见的皮肤镜表现模式为球状（n = 35 [50%]），其次是星芒状（n = 24 [34.3%]）、网状（n = 8 [11.4%]）和均匀状（n = 3 [4.3%]）。70例患者中有27例有随访数据。其中，21例在随访图像上显示有演变。27个病变中有6个表现为稳定模式（无演变）。出现演变的患者平均年龄比稳定组年轻（p = 0.04）。
基于我们的研究，Spitz痣最常见的生物学行为是演变。尽管在其他临床特征上未观察到显著差异，但在试图将Spitz痣与黑色素瘤区分开来时，演变与年龄之间的负相关关系是需要考虑的重要因素。
