Dermatology Unit, 1st Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Dermatology. 2011;222(3):256-60. doi: 10.1159/000326109. Epub 2011 Apr 13.
The natural evolution of melanocytic nevi is a complex, multifactorial process that can be studied by monitoring nevi on a long-term basis.
To assess the evolution pathway of Spitz nevi, lesions with clinical and dermoscopic features suggestive of Spitz nevi were monitored and baseline and follow-up images compared.
Sixty-four patients (mean age 10.4 years) with lesions suggestive of Spitz nevi were included. Lesions were monitored for a mean follow-up period of 25 months. Upon side-by-side evaluation of baseline and follow-up images, 51 (79.7%) lesions showed an involution pattern and 13 (20.3%) lesions showed a growing or stable pattern. No significant differences were found between growing and involving lesions in terms of patient age and sex and the location and palpability of lesions. The great majority of growing lesions were pigmented or partially pigmented (92.3%), whereas 47.1% of lesions in involution were amelanotic (p = 0.005).
In this series of lesions clinically and dermoscopically diagnosed as Spitz nevi, spontaneous involution seems to be the most common biologic behavior.
黑色素细胞痣的自然演变是一个复杂的、多因素的过程，可以通过长期监测痣来研究。
为了评估 Spitz 痣的演变途径，对具有临床和皮肤镜特征提示 Spitz 痣的病变进行监测，并比较基线和随访图像。
共纳入 64 例（平均年龄 10.4 岁）具有 Spitz 痣特征的患者。这些病变的平均随访时间为 25 个月。通过对基线和随访图像的并排评估，51 个（79.7%）病变显示出退行性模式，13 个（20.3%）病变显示出生长或稳定模式。在患者年龄、性别以及病变的位置和可触知性方面，生长性病变和退行性病变之间没有显著差异。绝大多数生长性病变是色素性或部分色素性的（92.3%），而退行性病变中 47.1%是无色素性的（p=0.005）。
在本系列临床和皮肤镜诊断为 Spitz 痣的病变中，自发性退行似乎是最常见的生物学行为。
