a Multiuser Center for Health (CMulti-Saúde) , Federal University of Sergipe , Sergipe , Brazil.
b Departament of Health Education , Federal University of Sergipe , Sergipe , Brazil.
Expert Opin Ther Pat. 2017 Oct;27(10):1147-1157. doi: 10.1080/13543776.2017.1349105. Epub 2017 Jul 10.
Fibromyalgia (FM) is a musculoskeletal condition characterized by chronic widespread pain, tenderness and often accompanied by other comorbid conditions such as depression, anxiety, chronic fatigue, among others. Now, we aimed to survey the recent patents describing new drugs or alternative therapy for FM. Areas covered: This review covers the therapeutic patents published between 2010 and 2017 from specialized search databases (WIPO, DERWENT, INPI, ESPANET and USPTO) that report the discovery of new drugs or pharmacologic alternative for the treatment of FM. Expert opinion: New therapeutic substances have been proposed in the last seven years. At least as it has been found in our survey, most are still in the pre-clinical phase of the study, and its clinical applicability is unclear. However, other therapeutic approaches were found in patents such as well-established drugs in the market in combination or drug repositioning that combines the 'new analgesic' effects with the old side effects. Hence, it is a safe approach for pharmaceutical market, but poorer to patients who need a radical innovation. So, there is the emerging need for further studies on the safety and efficacy of such therapeutic measures and the search for improvement of side effects, as well as the development of new drugs that are unorthodox for different FM symptoms.
纤维肌痛症（FM）是一种以慢性广泛性疼痛、压痛为特征的肌肉骨骼疾病，常伴有其他合并症，如抑郁、焦虑、慢性疲劳等。现在，我们旨在调查描述治疗 FM 的新药或替代疗法的最新专利。涵盖领域：本综述涵盖了 2010 年至 2017 年期间在专门的搜索数据库（WIPO、DERWENT、INPI、ESPANET 和 USPTO）中公布的治疗专利，这些专利报告了新药物或治疗 FM 的药理学替代物的发现。专家意见：在过去的七年中，已经提出了新的治疗物质。至少在我们的调查中发现，大多数物质仍处于研究的临床前阶段，其临床适用性尚不清楚。然而，在专利中发现了其他治疗方法，如市场上已确立的药物联合使用或药物重新定位，将“新型镇痛药”的效果与旧的副作用结合起来。因此，这对需要激进创新的患者来说是一个安全的方法。因此，需要对这些治疗措施的安全性和有效性进行进一步研究，并寻找改善副作用的方法，以及开发针对不同 FM 症状的非传统新药。
