Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, No.1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam 40170, Malaysia.
Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, No.1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam 40170, Malaysia.
Molecules. 2021 Feb 19;26(4):1107. doi: 10.3390/molecules26041107.
Despite the improvements in life expectancy, neurodegenerative conditions have arguably become the most dreaded maladies of older people. The neuroprotective and anti-ageing potentials of essential oils (EOs) are widely evaluated around the globe. The objective of this review is to analyse the effectiveness of EOs as neuroprotective remedies among the four common age-related neurodegenerative diseases. The literature was extracted from three databases (PubMed, Web of Science and Google Scholar) between the years of 2010 to 2020 using the medical subject heading (MeSH) terms "essential oil", crossed with "Alzheimer's disease (AD)", "Huntington's disease (HD)", "Parkinson's disease (PD)" or "amyotrophic lateral sclerosis (ALS)". Eighty three percent (83%) of the studies were focused on AD, while another 12% focused on PD. No classifiable study was recorded on HD or ALS. EO from has been recorded as one of the most effective acetylcholinesterase and butyrylcholinesterase inhibitors. However, only sp. has been assessed for its effectiveness in both AD and PD. Our review provided useful evidence on EOs as potential neuroprotective remedies for age-related neurodegenerative diseases.
尽管预期寿命有所提高，但神经退行性疾病无疑已成为老年人最可怕的疾病。全球范围内广泛评估了精油 (EO) 的神经保护和抗衰老潜力。本综述的目的是分析 EO 作为四种常见的与年龄相关的神经退行性疾病的神经保护疗法的有效性。文献从三个数据库（PubMed、Web of Science 和 Google Scholar）中提取，检索年限为 2010 年至 2020 年，使用的医学主题词 (MeSH) 术语为“essential oil”，与“Alzheimer's disease (AD)”、“Huntington's disease (HD)”、“Parkinson's disease (PD)”或“amyotrophic lateral sclerosis (ALS)”交叉。83%的研究集中在 AD 上，另外 12%的研究集中在 PD 上。HD 或 ALS 没有可分类的研究。已记录从 提取的 EO 是最有效的乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂之一。然而，只有 被评估了其在 AD 和 PD 中的有效性。我们的综述为 EO 作为与年龄相关的神经退行性疾病的潜在神经保护疗法提供了有用的证据。
