Bruker (UK) Ltd., Banner Lane, Coventry, CV4 9GH, UK.
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11779-11783. doi: 10.1002/anie.201705506. Epub 2017 Aug 18.
Nested NMR experiments combining up to five conventional NMR pulse sequences into one supersequence are introduced. The core 2D NMR techniques routinely employed in small molecule NMR spectroscopy, such as HSQC, HMQC, HMBC, COSY, NOESY, TOCSY, and similar, can be recorded in a single measurement. In this way the data collection time may be dramatically reduced and sample throughput increased for basic NMR applications, such as structure elucidation and verification in synthetic, medicinal, and natural product chemistry.
介绍了一种将多达五个常规 NMR 脉冲序列组合成一个超序列的嵌套 NMR 实验。在小分子 NMR 光谱学中常规使用的核心 2D NMR 技术，如 HSQC、HMQC、HMBC、COSY、NOESY、TOCSY 等，可以在单次测量中记录。这样可以显著减少数据采集时间，并提高基本 NMR 应用（如合成、药物和天然产物化学中的结构阐明和验证）的样品通量。
