NMR 方法在混合物分析中的应用。

Nantes Université, CNRS, CEISAM UMR6230, F-44000 Nantes, France.

Chem Commun (Camb). 2022 Dec 15;58(100):13855-13872. doi: 10.1039/d2cc05053f.

NMR spectroscopy is a powerful approach for the analysis of mixtures. Its usefulness arises in large part from the vast landscape of methods, and corresponding pulse sequences, that have been and are being designed to tackle the specific properties of mixtures of small molecules. This feature article describes a selection of methods that aim to address the complexity, the low concentrations, and the changing nature that mixtures can display. These notably include pure-shift and diffusion NMR methods, hyperpolarisation methods, and fast 2D NMR methods such as ultrafast 2D NMR and non-uniform sampling. Examples or applications are also described, in fields such as reaction monitoring and metabolomics, to illustrate the relevance and limitations of different methods.

NMR 光谱学是一种用于分析混合物的强大方法。它的用途很大程度上源于已经设计和正在设计的大量方法和相应的脉冲序列，这些方法旨在解决小分子混合物的特定性质。本文介绍了一系列旨在解决混合物的复杂性、低浓度和变化性质的方法。这些方法包括纯位移和扩散 NMR 方法、超极化方法以及快速二维 NMR 方法，如超快二维 NMR 和非均匀采样。还描述了在反应监测和代谢组学等领域的应用示例，以说明不同方法的相关性和局限性。