Yamamoto M, Sakurada T, Yoshida K, Kaise K, Kaise N, Fukazawa H, Suzuki M, Nomura T, Itagaki Y, Saito S
Tohoku J Exp Med. 1985 Aug;146(4):385-90. doi: 10.1620/tjem.146.385.
Thirty-four hyperthyroid patients were divided into four groups: placebo, carteolol (20 mg/day), indenolol (60 mg/day) and metoprolol (120 mg/day) groups. The heart rate was determined before and two weeks after the treatment with each drug. Serum levels of T4, T3 and rT3 were measured before, and one and two weeks after the treatment. Both indenolol and metoprolol significantly reduced the heart rate (p less than 0.01 and p less than 0.05, respectively), whereas carteolol was ineffective. Carteolol significantly decreased T4 from 23.4 +/- 4.4 micrograms/100 ml to 20.1 +/- 3.2 micrograms/100 ml (p less than 0.01) in one week and to 20.0 +/- 3.7 micrograms/100 ml (p less than 0.01) in two weeks. T3 and rT3 were also decreased significantly (p less than 0.05 and p less than 0.01, respectively) two weeks after the treatment with carteolol. After two weeks of indenolol treatment, T4 was decreased significantly from 26.2 +/- 8.5 micrograms/100 ml to 23.9 +/- 8.2 micrograms/100 ml (p less than 0.05) and T3 from 789 +/- 391 ng/100 ml to 592 +/- 340 ng/100 ml (p less than 0.02). Metoprolol had no effect on serum thyroid hormone levels. The decrease in the serum level of thyroid hormones by carteolol and indenolol but not by metoprolol in patients with hyperthyroidism would be due to the blockade of beta 2-adrenoreceptors concerning with thyroid hormone secretion.
34例甲状腺功能亢进患者被分为四组：安慰剂组、卡替洛尔（20毫克/天）组、吲哚洛尔（60毫克/天）组和美托洛尔（120毫克/天）组。在每种药物治疗前及治疗两周后测定心率。在治疗前、治疗一周后和治疗两周后测定血清T4、T3和反T3水平。吲哚洛尔和美托洛尔均显著降低心率（分别为p<0.01和p<0.05），而卡替洛尔无效。卡替洛尔在一周内使T4从23.4±4.4微克/100毫升显著降至20.1±3.2微克/100毫升（p<0.01），两周内降至20.0±3.7微克/100毫升（p<0.01）。卡替洛尔治疗两周后，T3和反T3也显著降低（分别为p<0.05和p<0.01）。吲哚洛尔治疗两周后，T4从26.2±8.5微克/100毫升显著降至23.9±8.2微克/100毫升（p<0.05），T3从789±391纳克/100毫升降至592±340纳克/100毫升（p<0.02）。美托洛尔对血清甲状腺激素水平无影响。甲状腺功能亢进患者中，卡替洛尔和吲哚洛尔可降低血清甲状腺激素水平，而美托洛尔则无此作用，这可能是由于与甲状腺激素分泌有关的β2-肾上腺素能受体被阻断所致。
