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心房交替：机制与临床意义。

Alternans in atria: Mechanisms and clinical relevance.

作者信息

Kanaporis Giedrius, Blatter Lothar A

机构信息

Department of Physiology & Biophysics, Rush University Medical Center, Chicago, USA.

Department of Physiology & Biophysics, Rush University Medical Center, Chicago, USA.

出版信息

Medicina (Kaunas). 2017;53(3):139-149. doi: 10.1016/j.medici.2017.04.004. Epub 2017 Jun 7.

DOI:10.1016/j.medici.2017.04.004
PMID:28666575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5802406/
Abstract

Atrial fibrillation is the most common sustained arrhythmia and its prevalence is rapidly rising with the aging of the population. Cardiac alternans, defined as cyclic beat-to-beat alternations in contraction force, action potential (AP) duration and intracellular Ca release at constant stimulation rate, has been associated with the development of ventricular arrhythmias. Recent clinical data also provide strong evidence that alternans plays a central role in arrhythmogenesis in atria. The aim of this article is to review the mechanisms that are responsible for repolarization alternans and contribute to the transition from spatially concordant alternans to the more arrhythmogenic spatially discordant alternans in atria.

摘要

心房颤动是最常见的持续性心律失常，且随着人口老龄化其患病率正在迅速上升。心脏交替脉，定义为在恒定刺激频率下收缩力、动作电位（AP）时程和细胞内钙释放的逐搏周期性交替，与室性心律失常的发生有关。最近的临床数据也提供了有力证据，表明交替脉在心房心律失常的发生中起核心作用。本文的目的是综述导致复极交替脉并促使心房从空间协调性交替脉转变为更易致心律失常的空间非协调性交替脉的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/420b36ff992b/nihms938769f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/c61af4b2de5c/nihms938769f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/20463a258f93/nihms938769f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/4213833af95e/nihms938769f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/420b36ff992b/nihms938769f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/c61af4b2de5c/nihms938769f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/1ce0b3a972ac/nihms938769f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/5d3242304c13/nihms938769f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/20463a258f93/nihms938769f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/4213833af95e/nihms938769f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d142/5802406/420b36ff992b/nihms938769f6.jpg

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J Interv Card Electrophysiol. 2017 Jan;48(1):89-97. doi: 10.1007/s10840-016-0185-7. Epub 2016 Sep 22.
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