Human Population Biology Research Group, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Human Population Biology Research Group, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Lilian and Marcel Pollak Chair of Biological Anthropology, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Bone. 2017 Oct;103:102-115. doi: 10.1016/j.bone.2017.06.020. Epub 2017 Jun 27.
Rheumatoid arthritis (RA) is characterized, among other factors, by systemic bone loss, reaching ~50% prevalence of osteoporosis in postmenopausal women. This is roughly a doubled prevalence in comparison with age-matched non-RA women. Postmenopausal RA women are more likely to be sero-positive for the anti-citrullinated peptide antibody (ACPA). Our extensive review of recent scientific literature enabled us to propose several mechanisms as responsible for the accelerated bone loss in ACPA(+) RA postmenopausal women. Menopause-associated estrogen deficiency plays a major role in these pathological mechanisms, as follows.
类风湿关节炎（RA）的特征是全身性骨质流失，绝经后妇女骨质疏松症的患病率约为 50%。与年龄匹配的非 RA 女性相比，这一比例大致增加了一倍。绝经后 RA 女性抗瓜氨酸化肽抗体（ACPA）呈阳性的可能性更大。我们对最近科学文献的广泛回顾使我们能够提出几种机制来解释 ACPA(+) RA 绝经后妇女骨丢失加速的原因。绝经相关的雌激素缺乏在这些病理机制中起着主要作用，如下所述。
