Kakehi Yoshiyuki, Sugimoto Mikio, Taoka Rikiya
Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Int J Urol. 2017 Sep;24(9):648-666. doi: 10.1111/iju.13380. Epub 2017 Jul 1.
These guidelines cover a wide range of topics from prostate cancer epidemiology to palliative care. Questions arising in daily clinical practice have been extracted and formulated as clinical questions. In the 4 years since the previous edition, there have been major changes - for example, robot-assisted prostatectomy has rapidly come into widespread use, and new hormones and anticancer drugs have been developed for castration-resistant prostate cancer. In response to these developments, the number of fields included in this guideline was increased from 11 in the 2012 edition to 16, and the number of clinical questions was increased from 63 to 70. The number of papers identified in searches of the existing literature increased from 4662 in the first edition, published in 2006, to 10 490 in the 2012 edition. The number of references has reached 29 448 just during this review period, indicating the exponential increase in research on the topic of prostate cancer. Clinical answers have been prepared based on the latest evidence. Recommendation grades for the clinical answers were determined by radiologists, pathologists, and other specialists in addition to urologists in order to reflect the recent advances and diversity of prostate cancer treatment. Here, we present a short English version of the original guideline, and overview its key clinical issues.
这些指南涵盖了从前列腺癌流行病学到姑息治疗等广泛主题。日常临床实践中出现的问题已被提取并整理为临床问题。自上一版发布后的4年里，出现了重大变化——例如，机器人辅助前列腺切除术已迅速广泛应用，并且针对去势抵抗性前列腺癌开发了新的激素和抗癌药物。针对这些进展，本指南涵盖的领域数量从2012版的11个增加到16个，临床问题数量从63个增加到70个。在现有文献检索中确定的论文数量从2006年出版的第一版中的4662篇增加到2012版中的10490篇。仅在本次审查期间，参考文献数量就已达到29448篇，这表明前列腺癌主题研究呈指数级增长。已根据最新证据准备了临床答案。除了泌尿科医生外，放射科医生、病理科医生和其他专家也参与确定临床答案的推荐等级，以反映前列腺癌治疗的最新进展和多样性。在此，我们呈现原始指南的简短英文版本，并概述其关键临床问题。
