非酒精性脂肪性肝病：与窒息作斗争——脂肪肝中的氧供应

Anavi Sarit, Madar Zecharia, Tirosh Oren

Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Israel; Peres Academic Center, Rehovot, Israel.

Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Israel.

Redox Biol. 2017 Oct;13:386-392. doi: 10.1016/j.redox.2017.06.008. Epub 2017 Jun 22.

Nonalcoholic fatty liver diseases (NAFLD) is one of the most common chronic liver disease in Western countries. Oxygen is a central component of the cellular microenvironment, which participate in the regulation of cell survival, differentiation, functions and energy metabolism. Accordingly, sufficient oxygen supply is an important factor for tissue durability, mainly in highly metabolic tissues, such as the liver. Accumulating evidence from the past few decades provides strong support for the existence of interruptions in oxygen availability in fatty livers. This outcome may be the consequence of both, impaired systemic microcirculation and cellular membrane modifications which occur under steatotic conditions. This review summarizes current knowledge regarding the main factors which can affect oxygen supply in fatty liver.

非酒精性脂肪性肝病（NAFLD）是西方国家最常见的慢性肝病之一。氧气是细胞微环境的核心组成部分，参与细胞存活、分化、功能及能量代谢的调节。因此，充足的氧气供应是组织耐久性的重要因素，主要对于高代谢组织，如肝脏而言。过去几十年积累的证据有力支持了脂肪肝中存在氧供应中断的情况。这一结果可能是系统性微循环受损和脂肪变性条件下发生的细胞膜修饰共同作用的结果。本综述总结了目前关于影响脂肪肝氧供应的主要因素的知识。