睡眠剥夺会诱发大鼠海马体中5-羟色胺（5-HT）作用及5-羟色胺受体表达的变化。
Sleep deprivation induces changes in 5-HT actions and 5-HT receptor expression in the rat hippocampus.
作者信息
Azizi H, Hwang J, Suen V, Kang N Z, Somvanshi R, Tadavarty R, Kumar U, Sastry B R
机构信息
Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Canada.
Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
出版信息
Neurosci Lett. 2017 Aug 10;655:151-155. doi: 10.1016/j.neulet.2017.06.053. Epub 2017 Jun 28.
A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.
12小时的睡眠剥夺会增强大鼠海马体中5-羟色胺（5-HT）1A受体的表达，而这种表达会在48小时的睡眠恢复后消退。在睡眠剥夺大鼠的海马体中，应用5-HT对CA1区记录的场兴奋性突触后电位的抑制作用也会增强。经过24或48小时的睡眠恢复后，5-HT作用的增强会消退。这些结果对治疗临床抑郁症具有启示意义。
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