Effect of sucralfate on the viscosity and retardation of hydrogen ion diffusion by gastric mucus glycoprotein.

The effect of an antiulcer drug (sucralfate) on the viscosity and the ability of pig gastric mucus glycoprotein to retard the diffusion of hydrogen ions was investigated. Preincubation with sucralfate produced a marked enhancement in the glycoprotein viscosity. This enhancement was concentration-dependent and at 1.0 X 10(-3) M sucralfate a 60% increase in viscosity was attained. Permeability measurements revealed that sucralfate caused a substantial improvement in the ability of the glycoprotein to retard the diffusion of hydrogen ions. At 1.0 X 10(-3) M sucralfate, permeability decreased by 25% and a 43% reduction was obtained with 1.0 X 10(-3) M sucralfate. It is suggested that sucralfate, by increasing the viscosity of the glycoprotein and by improving its ability to retard the diffusion of hydrogen ions, strengthens the integrity of gastric mucus.