Osaka Rie, Manabe Saki, Miyoshi Yukiko, Nakano Yuki, Yamashita Ayana, Shiragami Chieko, Hirooka Kazuyuki, Muraoka Yuki, Tsujikawa Akitaka
Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Graefes Arch Clin Exp Ophthalmol. 2017 Sep;255(9):1743-1748. doi: 10.1007/s00417-017-3717-7. Epub 2017 Jul 2.
To investigate the prevalence and characteristics of paravascular inner retinal abnormalities in healthy eyes.
In this prospective observational case series, we included 178 healthy eyes (178 patients) with no ocular diseases. Eyes with co-existing ocular diseases, e.g., epiretinal membrane, glaucoma, or high myopia, were excluded from the current study. The posterior pole and paravascular areas of the temporal arcade vessels were comprehensively examined by dense radial scanning of optical coherence tomography (OCT) with the extended field imaging technique.
On fundus photography, no inner retinal abnormalities were detected along the temporal arcade vessels. On OCT sections, paravascular inner retinal abnormalities were seen in 77 (43.3%) eyes. In 71 (39.9%) eyes, inner retinal cystoid or fissure-like spaces that had no connection to the vitreous cavity were seen adjacent to the temporal arcade vessels. Most of these lesions were detected only on several consecutive OCT sections. In four (2.2%) eyes, inner retinal cleavages with openings to the vitreous cavity were seen adjacent to the temporal arcade vessels. These lesions were more frequently detected in the inferior hemisphere and along the major retinal veins. No eyes showed typical broad defects of the inner retinal tissue. There were no significant differences in age, gender, visual acuity, refractive error, or axial length between eyes with or without paravascular inner retinal abnormalities.
Paravascular cystoid or fissure-like spaces were frequently seen in the inner retina of healthy eyes. However, we detected no typical paravascular inner retinal defects in healthy eyes.
研究健康眼中视网膜血管旁内层异常的患病率及特征。
在这个前瞻性观察性病例系列中，我们纳入了178只无眼部疾病的健康眼睛（178例患者）。本研究排除了患有并存眼部疾病的眼睛，例如视网膜前膜、青光眼或高度近视。采用扩展视野成像技术，通过光学相干断层扫描（OCT）的密集径向扫描对颞侧弓形血管的后极部和血管旁区域进行全面检查。
眼底照相显示，沿颞侧弓形血管未检测到视网膜内层异常。在OCT切片上，77只（43.3%）眼睛可见血管旁视网膜内层异常。在71只（39.9%）眼睛中，在颞侧弓形血管附近可见与玻璃体腔无连接的视网膜内层囊样或裂隙样间隙。这些病变大多仅在连续的几张OCT切片上被检测到。在4只（2.2%）眼睛中，在颞侧弓形血管附近可见与玻璃体腔相通的视网膜内层劈裂。这些病变在下半球和沿视网膜主要静脉处更常被检测到。没有眼睛表现出典型的视网膜内层组织广泛缺损。有无血管旁视网膜内层异常的眼睛在年龄、性别、视力、屈光不正或眼轴长度方面均无显著差异。
健康眼睛的视网膜内层常可见血管旁囊样或裂隙样间隙。然而，我们在健康眼睛中未检测到典型的血管旁视网膜内层缺损。
