Bhide P, Escriba M, Srikantharajah A, Joshi H, Gudi A, Shah A, Acharya G, Homburg R
Homerton Fertility Centre, Homerton University Hospital NHS Foundation Trust, London, E9 6SR, UK.
Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsö, Norway.
Arch Gynecol Obstet. 2017 Sep;296(3):583-587. doi: 10.1007/s00404-017-4453-2. Epub 2017 Jul 1.
Serum anti-Mullerian hormone shows a strong positive correlation to the quantitative ovarian reserve but its correlation to embryo quality is unclear. This study assessed the association between serum AMH as a marker of ovarian reserve and embryo quality, using the technology of time-lapse imaging of the embryos in women undergoing in vitro fertilisation (IVF) treatment.
304 embryos from 198 women undergoing IVF were included in the study. Serum AMH was assessed for all women. Embryo quality was assessed with the known implantation data (KID) score generated by the time-lapse imaging system.
There was no statistically significant difference in mean serum AMH among different KID score categories (p = 0.135). This remained non-significant after controlling for confounding variables (p = 0.305).
The results of our study show no significant association between serum AMH and embryo quality in women undergoing IVF treatment when embryo quality was assessed using the KID scores generated by time-lapse imaging which is a better method of embryo assessment rather than conventional morphological assessment.
血清抗苗勒管激素与卵巢储备量呈强正相关，但其与胚胎质量的相关性尚不清楚。本研究采用延时成像技术，对接受体外受精（IVF）治疗的女性胚胎进行评估，以探讨血清抗苗勒管激素作为卵巢储备标志物与胚胎质量之间的关联。
本研究纳入了198例接受IVF治疗女性的304枚胚胎。对所有女性进行血清抗苗勒管激素评估。采用延时成像系统生成的已知着床数据（KID）评分评估胚胎质量。
不同KID评分类别之间的血清抗苗勒管激素均值无统计学显著差异（p = 0.135）。在控制混杂变量后，这一差异仍无统计学意义（p = 0.305）。
当使用延时成像生成的KID评分评估胚胎质量时，本研究结果显示，接受IVF治疗的女性血清抗苗勒管激素与胚胎质量之间无显著关联。延时成像技术是一种比传统形态学评估更好的胚胎评估方法。
