Molecular Cellular Oncology Lab, Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Centre for Medical Genetics, Ghent University, Ghent, Belgium.
Molecular Cellular Oncology Lab, Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Inflammation Research Center (IRC), VIB, Ghent, Belgium.
Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):584-591. doi: 10.1016/j.bbcan.2017.06.006. Epub 2017 Jun 29.
Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.
胚胎上皮-间充质（EMT）程序的再激活通常被认为是癌进展的核心组成部分。近 20 年来，ZEB、SNAIL 和 TWIST 家族的 EMT 转录因子（EMT-TFs）被一起引用。这些 EMT-TFs 的最新研究扩展了它们的范围，它们作为 EMT 诱导因子的典型定义已经过时。新的见解需要重新评估这些转录因子及其在生理和病理条件下的多功能性，而不仅仅局限于细胞侵袭和扩散。
