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癌症转移中上皮-间质转化诱导转录因子的翻译后调控

The Post-Translational Regulation of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis.

作者信息

Kang Eunjeong, Seo Jihye, Yoon Haelim, Cho Sayeon

机构信息

Laboratory of Molecular and Pharmacological Cell Biology, College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.

出版信息

Int J Mol Sci. 2021 Mar 30;22(7):3591. doi: 10.3390/ijms22073591.

DOI:10.3390/ijms22073591
PMID:33808323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8037257/
Abstract

Epithelial-mesenchymal transition (EMT) is generally observed in normal embryogenesis and wound healing. However, this process can occur in cancer cells and lead to metastasis. The contribution of EMT in both development and pathology has been studied widely. This transition requires the up- and down-regulation of specific proteins, both of which are regulated by EMT-inducing transcription factors (EMT-TFs), mainly represented by the families of Snail, Twist, and ZEB proteins. This review highlights the roles of key EMT-TFs and their post-translational regulation in cancer metastasis.

摘要

上皮-间质转化（EMT）通常发生在正常胚胎发育和伤口愈合过程中。然而，这一过程也可能在癌细胞中发生并导致转移。EMT在发育和病理学中的作用已得到广泛研究。这种转化需要特定蛋白质的上调和下调，而这两种调节均由上皮-间质转化诱导转录因子（EMT-TFs）调控，主要包括Snail、Twist和ZEB蛋白家族。本综述重点介绍了关键EMT-TFs在癌症转移中的作用及其翻译后调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2633/8037257/2481ddda5dd9/ijms-22-03591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2633/8037257/bcba96383158/ijms-22-03591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2633/8037257/15fbf6c1ebff/ijms-22-03591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2633/8037257/2481ddda5dd9/ijms-22-03591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2633/8037257/bcba96383158/ijms-22-03591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2633/8037257/15fbf6c1ebff/ijms-22-03591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2633/8037257/2481ddda5dd9/ijms-22-03591-g003.jpg

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