Department of Microbiology &Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Nat Rev Immunol. 2017 Oct;17(10):647-660. doi: 10.1038/nri.2017.63. Epub 2017 Jun 26.
Efficient viral gene expression is threatened by cellular stress response programmes that rapidly reprioritize the translation machinery in response to varied environmental assaults, including virus infection. This results in inhibition of bulk synthesis of housekeeping proteins and causes the aggregation of messenger ribonucleoprotein complexes into cytoplasmic foci that are known as stress granules, which can entrap viral mRNAs. There is accumulating evidence for the antiviral nature of stress granules, which is supported by the discovery of many viral factors that interfere with stress granule formation and/or function. This Review focuses on recent advances in our understanding of the role of translation inhibition and stress granules in antiviral immune responses.
高效的病毒基因表达受到细胞应激反应程序的威胁，这些程序会迅速重新调整翻译机制，以应对各种环境攻击，包括病毒感染。这导致了管家蛋白的大量合成受到抑制，并导致信使核糖核蛋白复合物聚集到细胞质焦点中，这些焦点被称为应激颗粒，可以捕获病毒 mRNA。越来越多的证据表明应激颗粒具有抗病毒特性，这一特性得到了许多干扰应激颗粒形成和/或功能的病毒因子的发现的支持。本综述重点介绍了我们在翻译抑制和应激颗粒在抗病毒免疫反应中的作用方面的最新进展。
