Department of Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Avenue, M-334, Chicago, Illinois 60611, USA.
Nat Rev Immunol. 2017 Oct;17(10):608-620. doi: 10.1038/nri.2017.66. Epub 2017 Jul 3.
Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.
线粒体是重要的信号细胞器，决定着免疫命运。从 T 细胞到巨噬细胞，线粒体构成了定义每个免疫细胞亚群的各种代谢途径的枢纽。在这个中心位置，线粒体有助于控制决定免疫细胞功能的各种代谢决策点。在这篇综述中，我们讨论了线粒体代谢如何在不同的免疫细胞亚群中变化，代谢信号如何决定细胞命运，以及这种信号如何可能被靶向治疗。
