Mubarik Yusif, Boyetey Shadrach Tetteh, Aikins Anastasia Rosebud, Mutocheluh Mohamed
West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Greater Accra, Accra P.O. Box LG 54, Ghana.
Department of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, University of Ghana, Legon, Greater Accra, Accra P.O. Box LG 25, Ghana.
Toxins (Basel). 2025 May 20;17(5):256. doi: 10.3390/toxins17050256.
Ochratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. There is evidence that OTA impairs epithelial barrier integrity and macrophage function and induces elevated secretion of pro-inflammatory cytokines. In adaptive immunity, OTA regulates T-cell differentiation, particularly Th1 and Th17 subsets, and adversely impacts humoral immunity, ultimately leading to immune suppression.
赭曲霉毒素A（OTA）是一种具有多种不良健康影响的霉菌毒素。作者进行了一项系统综述，以评估OTA对免疫系统的影响，重点关注其对免疫器官、固有免疫和适应性免疫以及相关信号通路的影响。研究表明，接触OTA会破坏免疫器官的功能，导致体重减轻、组织学损伤以及抗体分泌细胞减少。有证据表明，OTA会损害上皮屏障完整性和巨噬细胞功能，并诱导促炎细胞因子分泌增加。在适应性免疫中，OTA调节T细胞分化，特别是Th1和Th17亚群，并对体液免疫产生不利影响，最终导致免疫抑制。
